山东医药2023，Vol.63Issue(34)：21-25,5.DOI:10.3969/j.issn.1002-266X.2023.34.005
血清LCN2、Apelin-17水平与急性缺血性卒中患者侧支循环形成的关系
Relationships between serum LCN2 and Apelin-17 levels and formation of collateral circulation in patients with acute ischemic stroke
摘要
Abstract
Objective To investigate the relationships between serum lipid transport protein 2(LCN2)and Angio-tensin Ⅱ receptor-like 1 endogenous ligand 17(Apelin-17)levels and the formation of collateral circulation in patients with acute ischemic stroke(AIS).Methods Totally 181 patients with AIS were selected as the AIS group,and were di-vided into the poor group of 69 cases and the good group of 112 cases according to the formation of collateral circulation,and another 60 healthy physical examiners were selected as the control group.Serum LCN2 and Apelin-17 levels were mea-sured by enzyme-linked immunosorbent assay.Multi-factor Logistic regression was used to analyze the factors influencing the poor formation of collateral circulation in AIS patients,and receiver operating characteristic(ROC)curves were used to analyze the predictive value of serum LCN2 and Apelin-17 levels on the poor formation of collateral circulation in AIS pa-tients.Results Compared with the control group,serum LCN2 level increased and Apelin-17 level decreased in the AIS group(both P<0.05).Multifactorial Logistic regression analysis showed that age(OR=1.048,95%CI:1.010 to 1.087),hypertension(OR=2.052,95%CI:1.034 to 4.072),diabetes mellitus(OR=2.127,95%CI:1.115 to 4.056),national institutes of health stroke scale score(OR=1.166,95%CI:1.049 to 1.296),and LCN2(OR=1.225,95%CI:1.127 to 1.331)were independent risk factors for poor collateral circulation formation,and Apelin-17(OR=0.947,95%CI:0.926 to 0.969)was an independent protective factor(all P<0.05).ROC curve analysis showed that the area under the curve(AUC)of serum LCN2 combined with Apelin-17(AUC=0.861,95%CI:0.802 to 0.908)in predicting poorly formed collateral circulation was greater than that of LCN2(AUC=0.764,95%CI:0.696 to 0.824)or Apelin-17(AUC= 0.765,95%CI:0.697 to 0.825)alone(both P<0.05).Conclusion Increased serum LCN2 levels and decreased Ape-lin-17 levels were independently associated with poor collateral circulation formation in patients with AIS,and serum LCN2 combined with Apelin-17 was of high value in predicting poor collateral circulation formation in patients with AIS.关键词
急性缺血性卒中/侧支循环/脂质运载蛋白2/血管紧张素Ⅱ受体样1内源性配体17Key words
acute ischemic stroke/collateral circulation/lipid transport protein 2/Angiotensin Ⅱ receptor-like 1 endogenous ligand 17分类
医药卫生引用本文复制引用
范志伟,谢振林,毕正强..血清LCN2、Apelin-17水平与急性缺血性卒中患者侧支循环形成的关系[J].山东医药,2023,63(34):21-25,5.基金项目
江苏省医学科研项目(JH19090). （JH19090）
