山东医药2023，Vol.63Issue(34)：26-30,5.DOI:10.3969/j.issn.1002-266X.2023.34.006
脉络膜血管指数联合血清CTRP9水平对糖尿病黄斑水肿发病风险的预测价值
Predictive value of CVI combined with serum CTRP9 level for risk of diabetic macular oedema
摘要
Abstract
Objective To investigate the predictive value of choroidal vascularity index(CVI)combined with serum complement 1q/tumor necrosis factor-related protein 9(CTRP9)level for the risk of diabetic macular edema(DME).Methods Totally 156 patients(156 eyes)with type 2 diabetes mellitus(T2DM)complicated with DR were selected as the DR group,and were divided into the DME group of 69 cases(eyes)and non-DME group of 87 cases(eyes)according to whether DME occurred or not,and 87 T2DM patients without DR in the same period were selected as the non-DR group.CVI was calculated using enhanced depth imaging optical coherence tomography,and serum CTRP9 levels were measured by enzyme-linked immunosorbent assay.Multifactorial Logistic regression was used to analyze the factors influencing the risk of DME in DR patients,and the predictive value of CVI combined with serum CTRP9 level for the risk of DME was an-alyzed by receiver operating characteristic(ROC)curve.Results Compared with the non-DR group,CVI and serum CTRP9 levels decreased in the DR group(both P<0.05).CVI and serum CTRP9 levels were lower in the DME group in comparison with those of the non-DME group(both P<0.05).Multifactorial Logistic regression analysis showed that in-creasing age,proliferative DR and elevated glycated hemoglobin were independent risk factors for the risk of DME in DR patients,and elevated CVI and CTRP9 were independent protective factors(all P<0.05).ROC curve analysis showed that the area under the curve of CVI and serum CTRP9 levels alone and in combination in predicting the risk of DME was 0.797,0.786,and 0.893,and the area under the curve of CVI combined with serum CTRP9 levels was the largest(all P<0.05).Conclusions Reduced CVI and serum CTRP9 levels were independently associated with the risk of DME,and CVI combined with serum CTRP9 levels had a high predictive value for the development of DME.关键词
糖尿病/糖尿病黄斑水肿/脉络膜血管指数/补体1q/肿瘤坏死因子相关蛋白9Key words
diabetes mellitus/diabetic macular edema/choroidal vascularity index/complement 1q/tumor necro-sis factor-related protein 9分类
医药卫生引用本文复制引用
杨来庆,罗广娥,张沧霞,王庆金,刘文,葛含笑,马元松..脉络膜血管指数联合血清CTRP9水平对糖尿病黄斑水肿发病风险的预测价值[J].山东医药,2023,63(34):26-30,5.基金项目
河北省中医药管理局中医药类科研资助项目(2023266) （2023266）
河北省中医药管理局中医药类科研资助项目(2017146). （2017146）
