同位素2023，Vol.36Issue(6)：612-619,8.DOI:10.7538/tws.2023.36.06.0612
103Pd核素分离纯化方法研究及质量控制
Research on Separation,Purification and Quality Control of 103Pd
摘要
Abstract
103Pd is commonly used in brachytherapy,especially in the aspect of prostate cancer and choroidal melanoma treatment.At present,103Pd is mainly produced by proton bombardment of rhodium target by cyclotron,and purified by extraction or ion exchange resin.In this work,the separation effects of AG 1-X 8 and AG MP-1 anionic resins were compared by using simulated samples under different chemical procedures,including such as hydrochloric acid concentrations of samples,elution methods,compo-sition of desorption solutions.Under the optimized condition,using AG 1-X 8 resin,Rh matrix and other metal impurities are eluted by 6 mol/L HCl and 0.03 mol/L HCl.Pd is desorbed by mixing 1 mol/L ammonia and 1 mol/L ammonium chloride in equal volume,the recovery of Pd is nearly 100%,and the product has the largest Pd/Rh ratio.By this method,three batches of 103Pd were produced,and the radioactive concen-tration,specific activity and radionuclide purity of 103Pd were greater than 6 GBq/mL,800 GBq/mg(EOS)and 99.9%,respectively.According to the requirements of the 2020 edition of the Chinese Pharmacopoeia for detection methods,the methodological valida-tion of the analytical methods for the purity of radionuclide and the content of Pd elements was carried out in terms of exclusivity,limit of detection and limit of quantifi-cation,linearity,precision and accuracy,to ensure the accuracy and reliability of the test results.关键词
103Pd/铑靶/分离纯化/质量控制/方法验证Key words
103Pd/Rh target/separation and purification/quality control/verification分类
能源科技引用本文复制引用
王晓明,段菲,马承伟,褚浩淼,李光,王春林,王成志,温凯..103Pd核素分离纯化方法研究及质量控制[J].同位素,2023,36(6):612-619,8.基金项目
中核集团"青年英才"项目 （）
