同位素2023，Vol.36Issue(6)：633-645,13.DOI:10.7538/tws.2022.youxian.083
靶向多巴胺D3受体PET分子探针的研究进展
Research Progress of PET Molecular Probes Targeting Dopamine D3 Receptor
摘要
Abstract
Dopamine D3 receptors are closely related to drug addiction,Parkinson's dis-ease(PD),schizophrenia and other neuropsychiatric diseases.PET imaging agents that target dopamine D3 receptors can noninvasively show changes in receptor density and status,thus revealing the origin and development process of disease and providing a basis for treatment.However,because dopamine D3 receptors have high similarity with D2 receptors hinders the selectivity of existing D3 receptors PET imaging agents,which limits the study of the mechanism of action of dopamine D3 receptors in neural networks.It is of great significance to develop high specificity,affinity,selective D3 receptor probe for the diagnosis and treatment of diseases of the central nervous system.This article reviewed the 18 F and 11 C radiolabeled PET molecular probes including tetra-hydropyrrole derivatives,aminotetralin derivatives and phenylpiperazines derivatives.Furthermore,the challenges in the development of D3 receptor probes also be discussed,aiming to provide valuable insights for future probe advancements.关键词
正电子发射计算机断层扫描/多巴胺D3受体/分子探针Key words
positron emission computed tomography/dopamine D3 receptor/molecular probe分类
能源科技引用本文复制引用
张格,薛井泉,赵世伦,刘宇,杨文江..靶向多巴胺D3受体PET分子探针的研究进展[J].同位素,2023,36(6):633-645,13.基金项目
国家自然科学基金资助项目(12175270,U2067214) （12175270,U2067214）
北京市自然科学基金资助项目(2202063) （2202063）
山东省自然科学基金资助项目(ZR2021M A104) （ZR2021M A104）
