眼科新进展2023，Vol.43Issue(12)：975-978,4.DOI:10.13389/j.cnki.rao.2023.0193
青光眼患者角膜滞后量与视网膜神经纤维层厚度之间的关系
Relationship between corneal hysteresis and retinal nerve fiber layer thick-ness in glaucoma
摘要
Abstract
Objective To investigate the relationship between corneal hysteresis(CH)and retinal nerve fiber layer(RNFL)thickness in patients with glaucoma.Methods In this study,186 eyes of 133 patients with open-angle glaucoma who attended the ophthalmology department of our hospital were included,with a follow-up of(3.8±0.8)years and an average of 9 visits.The CH measurements were acquired using the Ocular Response Analyzer,and RNFL thickness was measured at each follow-up using spectral domain optical coherence tomography.All statistical analyses were performed with Stata software.Univariate and multivariable linear regression models were used to investigate the relationship between age,baseline CH,intraocular pressure(IOP),central corneal thickness(CCT)and RNFL thickness.Results The aver-age baseline CH was(9.2±1.8)mmHg(1 kPa=7.5 mmHg),average baseline RNFL thickness was(76.4±18.1)μm,the average baseline IOP was(13.8±3.7)mmHg,and the average baseline CCT was(533±42)μm.Univariate model analysis showed that the baseline CH had a positive correlation with RNFL thickness(P＜0.05).The lower the CH,the thinner the RNFL.For every 1 mmHg reduction in CH,the thickness of RNFL was reduced by 0.13 μm,indicating that CH may be involved in the occurrence and development of glaucoma.The univariate model analysis also showed that there was a negative correlation between IOP and RNFL thickness(P＜0.05).The higher the IOP,the thinner the RNFL.However,there was no significant correlation between age,CCT and RNFL thickness(both P＞0.05).The multivariate model analy-sis showed that there was a positive correlation between baseline CH and RNFL thickness during the follow-up,excluding the influence of age,IOP and CCT(P＜0.05).For every l mmHg reduction in CH,the thickness of RNFL was reduced by 0.13 μm.Conclusion There is a positive correlation between baseline CH and RNFL thickness in glaucoma.The lower the CH,the thinner the RNFL.Low CH may be a risk factor for the progression of glaucoma.关键词
角膜滞后量/视网膜神经纤维层/青光眼/角膜生物力学Key words
corneal hysteresis/retinal nerve fiber layer/glaucoma/corneal biomechanics分类
医药卫生引用本文复制引用
杨聪聪,罗茜,张春巍..青光眼患者角膜滞后量与视网膜神经纤维层厚度之间的关系[J].眼科新进展,2023,43(12):975-978,4.基金项目
黑龙江省自然科学基金项目(编号:LH2020H041) （编号:LH2020H041）
哈尔滨医科大学附属第一医院科研创新基金项目(编号:2020M23) （编号:2020M23）
黑龙江省残疾人福利基金会资助项目(编号:2023IIT088) （编号:2023IIT088）
