中风与神经疾病杂志2023，Vol.40Issue(11)：976-982,7.DOI:10.19845/j.cnki.zfysjjbzz.2023.0211
中老年突发感音神经性聋患者脑小血管病负荷的危险因素分析
An analysis of the risk factors for cerebral small vessel disease burden in middle-aged and elderly patients with sudden sensorineural hearing loss
摘要
Abstract
Objective To examine the risk factors for increased burden of cerebral small vessel diseases(CSVD)in middle-aged and elderly patients with sudden sensorineural hearing loss(SSNHL).Methods The data were retrospec-tively collected from middle-aged and elderly patients who were admitted to the hospital due to SSNHL between May 2019 and May 2023.The patients were analyzed for their clinical manifestations,hearing test results,and radiological features.All enrolled patients were assessed for total CSVD burden,and patients with varying degrees of burdens(0,1,2,and≥3 points)were compared for their differences in the clinical features and hearing features.Ordinal logistic regression was conducted to identify the independent risk factors for increased total CSVD burden in middle-aged and elderly patients with SSNHL.Results A total of 206 patients with SSNHL were enrolled,including 94 males and 112 females,with an average age of(58.70±7.98)years.The numbers of patients with a total CSVD burden of 0、1、2,and≥3 points were 108(52.4%),54(26.2%),29(14.0%),and 15(7.2%),respectively.Univariate analysis showed significant differences between different CSVD burden groups in age,hypertension status,history of drinking,low-density lipoprotein>3.1 mmol/L,and presence of dizziness at the onset of disease(P<0.05).Logistic regression analysis demonstrated that aging(OR=1.050;95%CI 1.023-1.077),hypertension(OR=1.584;95%CI 1.036-2.422),history of drinking(OR=2.304;95%CI 1.415-3.754),and presence of dizziness at the onset of disease(OR=1.691;95%CI 1.085-2.637)were independent risk factors for in-creased CSVD burden in SSNHL patients aged 45 years and above.Conclusion Aging,hypertension,history of drink-ing,and dizziness at the onset of disease are independent risk factors for increased CSVD burden in middle-aged and el-derly patients with SSNHL.Clinicians should conduct radiological evaluations on these patients to identify pa-tients with CSVD at an early stage.关键词
突发感音神经性聋/脑小血管病/脑白质病变/危险因素/核磁共振Key words
Sudden sensorineural hearing loss/Cerebrovascular small vessel disease/Cere-bral white matter lesion/Risk factor/Magnetic resonance imaging分类
医药卫生引用本文复制引用
钟瑶,李红艳,刘改芬,方瑞乐,王现蕾,赵性泉,鞠奕..中老年突发感音神经性聋患者脑小血管病负荷的危险因素分析[J].中风与神经疾病杂志,2023,40(11):976-982,7.基金项目
中国医学科学院临床与转化医学研究专项(2022-I2M-C&T-B-116) （2022-I2M-C&T-B-116）
科技创新 2030-"脑科学与类脑研究"重大项目(2022ZD0211805) （2022ZD0211805）
