中风与神经疾病杂志2023，Vol.40Issue(11)：983-988,6.DOI:10.19845/j.cnki.zfysjjbzz.2023.0212
肠道微生物和前庭功能障碍之间的因果关系:孟德尔随机化研究
Causal relationship between gut microbiota and vestibular dysfunction:a mendelian randomization study
摘要
Abstract
Objective Previous research has indicated a discernible association between gut microbiota and ves-tibular dysfunction;however,further investigation is required to establish a causal relationship.This study aims to com-prehensively study the causal relationship between gut microbiota and vestibular dysfunction and determine the species of related gut microbes.Methods A two-sample Mendelian randomization analysis was performed.The gut microbiome data of 18 340 individuals obtained from the genome-wide association study(GWAS)by the MiBioGen consortium in 2021 were used as the exposure samples.The GWAS data related to vestibular dysfunction were used as the outcome samples.The inverse variance weighting method was employed to analyze the gut microbiome data.The results were assessed based on the odds ratio(OR)as the effect index with 95%confidence interval(CI).The stability and reliability of the findings were assessed using the leave-one-out,heterogeneity,horizontal pleiotropy,and false discovery rate approaches.Results The results indicated a significant association between an elevated abundance of Bifidobacterium and a de-creased risk of vestibular dysfunction.Furthermore,the leave-one-out method confirmed the stability of the results and the absence of instrumental variables exerting substantial influence on the findings.The causal relationship was negative.The influence of heterogeneity and horizontal pleiotropy on the causal effect could be eliminated.Conclusion Bifidobacte-rium may affect vestibular dysfunction by influencing 5-HT through the"gut-brain axis",but this result still needs further verification.关键词
孟德尔随机化/肠道微生物/前庭功能障碍/因果关系Key words
Mendelian randomization/Gut microbiota/Vestibular dysfunction/Causal relationship分类
医药卫生引用本文复制引用
张彬,滕鑫,吴彤,韩琦,董晗硕,刘寅,项颗,孙莉..肠道微生物和前庭功能障碍之间的因果关系:孟德尔随机化研究[J].中风与神经疾病杂志,2023,40(11):983-988,6.基金项目
吉林省自然科学基金(YDZJ202301ZYTS430) （YDZJ202301ZYTS430）
