摘要
Abstract
Objective To explore the effects of valproate on vestibular migraine(VM)symptom improvement and vestibular function.Methods The patients with VM treated in the Dizziness Diagnosis and Treatment Center of The Sec-ond Affiliated Hospital of Naval Medical University from September 1,2019 to May 1,2021 were randomly divided into Valproate group and Flunarizine group.The patients were treated with valproate or flunarizine for three months.Before and after the treatment,the frequency of VM as well as the scores of Visual Analogue Scale(VAS)and Dizziness Handi-cap Inventory(DHI)items were recorded.Vestibular function was compared in the Valproate group before and after treat-ment.Results The VM frequency,the total scores of VAS and DHI,and the scores of VAS and DHI items in both groups were significantly reduced after the treatment.The changes in VM frequency,VAS score,DHI-F score,DHI-P score,and total DHI score before and after treatment were significantly greater in the Valproate group than in the Flunari-zine group.There was no significant difference in the variation of DHI-E score before and after treatment between the two groups.Abnormal eye movement,gaze,and spontaneous nystagmus decreased significantly in the Valproate group after treatment.There were no significant differences in abnormal caloric test,c-VEMP,o-VEMP,saccade test,smooth pursuit test,and direction-changing positional nystagmus.Conclusion Valproate can significantly improve the symptoms of VM and reduce its frequency.Valproate is more efficient than flunarizine.关键词
前庭性偏头痛/丙戊酸钠/预防性治疗/前庭功能Key words
Vestibular migraine/Valproate/Preventive treatment/Vestibular function分类
医药卫生
