局解手术学杂志2023，Vol.32Issue(12)：1025-1028,4.DOI:10.11659/jjssx.12E022151
颈椎钩椎关节退行性变对VEGF及其受体表达的影响
Effect of cervical Luschka joint degenerative change on expression of VEGF and its receptor
摘要
Abstract
Objective To observe the effect of cervical degenerative change on the expression of vascular endothelial growth factor(VEGF)and vascular endothelial growth factor receptor-2(VEGFR-2).Methods The C3 to C7 segments of bilateral healthy cervical vertebrae of adult cadavers were taken as the control group,and the C3 to C7 segments of bilateral degenerative cervical vertebrae of adult cadavers were taken as the experimental group.The expression changes of VEGF and VEGFR-2 of the two groups were observed and analyzed by immunohistochemistry,immunofluorescence staining and real-time quantitative PCR.Results The protein and mRNA expressions of VEGF and VEGFR-2 in the experimental group were higher than those in the control group,with statistically significant differences(P<0.05).Conclusion Cervical Luschka joint degenerative change significantly up-regulates the expression of VEGF and VEGFR-2,which is closely related to the microenvironmental changes around the Luschka joint caused by degeneration of joint-like structure.关键词
颈椎/钩椎关节/退行性变/VEGF/VEGFR-2Key words
cervical vertebra/Luschka joint/degenerative change/VEGF/VEGFR-2分类
医药卫生引用本文复制引用
陈杰,史君,王星,李琨,张少杰,李筱贺,高尚,王海燕,李志军,马渊,赵丹阳..颈椎钩椎关节退行性变对VEGF及其受体表达的影响[J].局解手术学杂志,2023,32(12):1025-1028,4.基金项目
国家自然科学基金(81860382 （）
81860383) （）
内蒙古自然科学基金(2020MS03061 （）
2020MS08109 （）
2019MS08017 （）
2019MS08319 （）
2022SHZR0151) （）
内蒙古自治区科技发展计划项目(2019GG158) （2019GG158）
内蒙古自治区卫生健康委医疗卫生科技计划项目(202201217) （202201217）
内蒙古自治区高等学校青年科技英才项目(NJYT22009) （NJYT22009）
内蒙古医科大学科研重点项目(YKD2021ZD011) （YKD2021ZD011）
