中国药理学通报2023，Vol.39Issue(12)：2205-2210,6.DOI:10.12360/CPB202204046
天然小分子保护炎症性肠病中肠上皮紧密连接屏障的研究进展
Advances in the study of natural small molecules to protect the intestinal epithelial tight junction barrier in inflammatory bowel disease
摘要
Abstract
Inflammatory bowel disease(IBD),as an idiopathic inflammatory disease of the intestinal tract,consisting mainly of Crohn's disease and ulcerative colitis,which can involve the rec-tum,colon and ileum,and whose pathogenesis is still not fully understood.The initiation of intestinal inflammation associated with IBD and its chronicity begins with increased intestinal per-meability caused by intestinal epithelial barrier disruption.The anti-permeability of the intestinal epithelial barrier is maintained by tight junction in the apical region of the intestinal epithelial cells,and disruption of the tight junction structure is closely as-sociated with intestinal epithelial barrier damage and the devel-opment of IBD.Therefore,it is significant to find drugs for the prevention and treatment of IBD using tight junctions as regulato-ry targets.In recent years,many small molecules of natural product origin have been reported to improve the effects of IBD.In particular,we review the compounds that have the function of repairing intestinal epithelial barrier and protecting tight junction structure,in order to provide research ideas for the design and development of new drugs for the prevention and treatment of IBD.关键词
炎症性肠病/肠上皮屏障/紧密连接/天然小分子化合物/肠上皮细胞/肠道通透性Key words
inflammatory bowel disease/intestinal epithelial barrier/tight junctions/natural small molecule compounds/in-testinal epithelial cells/intestinal permeability分类
医药卫生引用本文复制引用
钟玉婷,王志斌,张立超..天然小分子保护炎症性肠病中肠上皮紧密连接屏障的研究进展[J].中国药理学通报,2023,39(12):2205-2210,6.基金项目
国家自然科学基金资助项目(No 81973551) （No 81973551）
上海市卫健委科研项目[[0-9] [0-9] ZY(2021-2023)-0203-04] （2021-2023）
