肿瘤药学2023，Vol.13Issue(5)：533-541,9.DOI:10.3969/j.issn.2095-1264.2023.05.02
肿瘤细胞死亡对细胞增殖的双重调控
Dual regulation of tumor cell death on cell proliferation
摘要
Abstract
Cell proliferation and cell death are fundamental processes that control the growth and development of the whole living organisms.The abnormal regulation of cell proliferation and cell death result in the uncontrolled and continu-ous proliferation of cells,which become the characteristic of cancer.Initially,it was thought that cell death was a common tumor suppressor mechanism,and this property was used in cancer therapy.However,with the increasing understanding of cell death,it has been found that dead cells can promote tumor cell proliferation,which in turn leads to tumor progression.Therefore,this article briefly reviewed the research status of several different regulatory cell death(RCD)in tumor cell pro-liferation,including apoptosis,pyroptosis and autophagy,and summarized the in-depth understanding of how these cell death modes as a"double-edged sword"affect cell proliferation through the cell cycle,in order to provide theoretical basis and new ideas for the prevention and treatment of cancer.关键词
细胞凋亡/细胞焦亡/细胞自噬/肿瘤细胞增殖/细胞周期Key words
Apoptosis/Pyroptosis/Autophagy/Tumor cell proliferation/Cell cycle分类
医药卫生引用本文复制引用
栾璐璐,董珊珊,王冉冉,李倩倩,曾勇..肿瘤细胞死亡对细胞增殖的双重调控[J].肿瘤药学,2023,13(5):533-541,9.基金项目
国家自然科学基金青年科学基金(81201730) （81201730）
湖南省自然科学基金(12JJ5073) （12JJ5073）
湖南省科技厅重点研发项目(2018SK2126). （2018SK2126）
