中山大学学报（医学科学版）2023，Vol.44Issue(6)：949-957,9.
基于特征解构策略识别与颅脑损伤患者日常生活能力受损相关的急性期特征
Feature Deconstruction Strategy Based Identification of Acute Features Associated With Impairment of Activities of Daily Living in Patients With Traumatic Brain Injury
摘要
Abstract
[Objective]To identify acute phase features associated with the prognosis of traumatic brain injury(TBI).[Methods]Through two traditional strategies,correlation analysis and prediction model,and one innovative research strat-egy based on feature deconstruction,a retrospective analysis was conducted using demographic,acute phase and chronic phase features of 354 TBI patients to identify acute phase features associated with activities of daily living(ADL)in chron-ic phase of TBI.For feature deconstruction strategy,the LASSO(Least Absolute Shrinkage and Selection Operator)algo-rithm was used to build a prediction model that could effectively predict ADL based on non-ADL chronic phase features.The model could indicate the key chronic phase dimensions determining the ADL in TBI patients.We then identified demo-graphic and acute phase variables that were significantly associated with these key chronic phase features.[Results]The feature deconstruction strategy revealed that ADL could be deconstructed into chronic phase dimensions such as weak limbs in TBI population.Importantly,to the best of our knowledge,this strategy revealed for the first time the association of these important acute phase features with specific chronic phase impairment features.For example,TBI patients had a higher risk for chronic phase recent memory impairment if they had a prolonged coma time and low GCS scores at acute phase[scaled coma time OR95%CI = 94.288(35.095,273.231);scaled GCS OR95%CI = 0.068(0.030,0.147)];the patients had a higher risk for insight impairment and disorientation at chronic phase if they had hydrocephalus at acute phase[insight impairment OR95%CI = 6.760(3.653,12.855);disorientation OR95%CI = 6.538(3.530,12.490)].All strategies showed that the strongest risk factors for ADL damage in the chronic phase included prolonged coma time and low GCS scores as well as hydrocephalus.[Conclusion]This study provides an innovative research strategy to establish the association between acute injury features and chronic recovery features,and to identify demographic and acute phase fea-tures associated with the prognosis of TBI.关键词
创伤性颅脑损伤/日常生活能力/预测模型/LASSO/急性期Key words
traumatic brain injury/ADL/prediction model/LASSO/acute phase分类
社会科学引用本文复制引用
刘迎,王婕妤,朱陈淮玉,林心意,孙艺航,时燕薇,曾燕妮..基于特征解构策略识别与颅脑损伤患者日常生活能力受损相关的急性期特征[J].中山大学学报（医学科学版）,2023,44(6):949-957,9.基金项目
国家自然科学基金(81772032) （81772032）
科技创新2030(2021ZD0202000) （2021ZD0202000）
