基于倾向评分回归调整探讨艾灸治疗常年变应性鼻炎灸感与灸效的前瞻性队列研究OA

Objective:To compare the effect of moxibustion on perennial allergic rhinitis(PAR)with different moxibustion sensations(heat sensitive moxibustion vs resting moxibustion)at the same acupuncture point(Shangyitang)by using tendency score regression adjustment(PSRA)balanced baseline data.Methods:A prospective cohort study was designed and 106 qualified subjects were included.Moxibustion sensation was stimulated by moxibustion with moxibustion stick.According to the sensation of heat moxibustion,they were naturally divided into heat moxibustion group(n=69)and traditional moxibustion(n=37).Both groups were treated with moxibustion in Shangyin Tang for 30min each time,once a day for two weeks,a total of 12 times.The outcome measures were Variable rhinitis Symptom Scale(TNSS),concomitant Symptom Scale(TNNSS)and Quality of Life questionnaire(RQLQ).Result:PSM was used for 1:1 matching with a matching tolerance of 0.02,and 25 pairs were successfully matched with a to-tal of 50 patients.There was no significant difference in baseline data between the two groups(P>0.05).After matching,the TNSS score of the ther-mosensitive group after treatment was 4.01±1.52,which was lower than that of the static group(5.42±1.10),with statistical significance(P<0.01).TNNSS score of the thermosensitive group was 1.26±0.43,which was lower than that of the static group(1.52±0.50),with statistical significance(P<0.01).The RQLQ score of the thermal group was 37.62±6.01,which was lower than that of the static group(47.22±7.76),with statistical significance(P<0.01).This suggests that the static group has therapeutic advantages in improving symptoms,signs and quality of life in PAR patients.The results of univariate analysis with differences before propensity score matching were included in multivariate logistic regression analysis.The results showed that drug use and disease course were independent risk factors for the efficacy of moxibustion(P<0.05).Conclusion:The clinical effect of moxibustion heat sensitive acupoint therapy on PAR is better than that of rest state group.