中医康复2024，Vol.1Issue(1)：47-50,4.DOI:10.19787/j.issn.2097-3128.2024.01.010
电针治疗脊髓损伤后神经源性膀胱信号通路研究进展
Research Progress on Neurogenic Bladder Signaling Pathways after Electroacupuncture in the Treatment of Spinal Cord Injury
摘要
Abstract
Neurogenic bladder is one of the most common complications in patients with spinal cord injury,and the urinary system caused by it causes varying degrees of dysfunction,which brings great pain to patients and their families.Electroacupuncture can improve neurogenic bladder symptoms after spinal cord injury by regulating multiple signaling pathways in vivo,and the pituitary adenylate cyclase activates peptide/cyclic ad-enosine monophosphate/protein kinase A(PACAP/cAMP/PKA)signaling pathway,Wnt/β-catenin signaling pathway,phosphatidylinositol-3-kinase/protein kinase B/mammalian rapamycin target(PI3K/AKT/mTOR)signaling pathway has become a research hotspot,but the following aspects still need to be paid attention to:Experimental studies mostly focus on a single signal pathway,and the interaction between each signal pathway needs to be further verified.Electroacupuncture can activate signaling pathways in vivo,but the expression detection of signaling molecules and other related transcriptional proteins in the downstream and downstream of related pathways is still lacking.The effects of different acupuncture points on various signaling pathways and signaling molecules need to be further studied.The specific mechanism of electroacupuncture in improving neurogenic blad-der function after spinal cord injury by activating the JAK-STAT signaling pathway needs to be further explored.关键词
电针/脊髓损伤后神经源性膀胱/信号通路Key words
electroacupuncture/Neurogenic bladder after spinal cord injury/Signal path分类
医药卫生引用本文复制引用
庞永强,徐彦龙,徐秀梅,董春璇..电针治疗脊髓损伤后神经源性膀胱信号通路研究进展[J].中医康复,2024,1(1):47-50,4.基金项目
甘肃省自然科学基金(编号:22JR5RA618) （编号:22JR5RA618）
甘肃省青年科技基金(编号:21JR7RA592) （编号:21JR7RA592）
