北华大学学报（自然科学版）2024，Vol.25Issue(1)：66-70,5.DOI:10.11713/j.issn.1009-4822.2024.01.012
替吉奥联合三维适形放疗治疗食管癌疗效及对心脏损伤和毒副反应的影响
Effect of S-1 Combined with Three-dimensional Conformal Radiotherapy on Esophageal Cancer and Its Influences on Heart Injury and Toxicity
摘要
Abstract
Objective To explore the curative effect of Tegafur,Gimeracil and Oteracil Porassium Capsules(S-1)combined with three-dimensional conformal radiotherapy on esophageal cancer and its influences on heart injury and toxicity.Method A total of 92 patients with advanced esophageal cancer undergoing chemoradiotherapy were divided into observation group and control group by random parity numbering method,46 cases in each group.The patients in control group were treated with three-dimensional conformal radiotherapy,while those in observation group were additionally treated with S-1,all were continuously treated for 6 weeks.The short-term clinical curative effect in both groups was observed.Before and after treatment,fasting peripheral venous blood was drawn to detect levels of cytokeratin 19 fragment(CYFRA21-1),carcinoembryonic antigen(CEA),squamous cell carcinoma antigen(SCC),cardiac troponin I(cTnI),myoglobin(Mb)and creatine kinase-MB(CK-MB).The occurrence of toxicity during radiotherapy in both groups was recorded.Results There was no significant difference in total remission rate between observation group and control group(50.00%vs 41.30%)(P＞0.05).The disease control rate in observation group was higher than that in control group(93.48%vs 78.26%)(P＜0.05).After treatment,levels of CYFRA21-1,CEA and SCC in both groups decreased(P＜0.05),which were lower in observation group than control group(P＜0.05).The levels of cTnI,Mb and CK-MB in both groups increased(P＜0.05).There was no significant difference in the above indexes between two groups(P＜0.05).There was no significant difference in toxicity between the two groups(P＞0.05).Conclusion The clinical curative effect of three-dimensional conformal radiotherapy combined with S-1 is better than that of three-dimensional conformal radiotherapy alone on esophageal cancer,with better safety.关键词
食管癌/替吉奥/三维适形放疗/临床疗效/心脏损伤/毒副反应Key words
esophageal cancer/Tegafur/three-dimensional conformal radiotherapy/clinical efficacy/heart injury/toxicity分类
医药卫生引用本文复制引用
邹亚,钟萍,罗楠,詹庭亭,荣丽雯..替吉奥联合三维适形放疗治疗食管癌疗效及对心脏损伤和毒副反应的影响[J].北华大学学报（自然科学版）,2024,25(1):66-70,5.基金项目
成都市医学科研基金项目(2021408). （2021408）
