北京大学学报（医学版）2023，Vol.55Issue(6)：1058-1061,4.DOI:10.19723/j.issn.1671-167X.2023.06.016
抗磷脂酰丝氨酸/凝血酶原抗体与不明原因复发性流产的相关性分析
Correlation of anti-phosphatidylserine/prothrombin antibodies with unexplained re-current miscarriages
摘要
Abstract
Objective:To investigate whether anti-phosphatidylserine/prothrombin antibodies and its IgG or IgM subtypes were correlated with unexplained recurrent miscarriages.Methods:In our a single-center retrospective study,283 patients with at least one unexplained miscarriage who visited the Third Hospital of Peking University between January 2021 and August 2023,aged between 18-40 years,and tested for anti-phosphatidylserine/prothrombin antibodies IgG or IgM subtypes,were included.The pa-tients with either positive IgG or IgM anti-phosphatidylserine/prothrombin antibody were regarded as posi-tive for anti-phosphatidylserine/prothrombin antibody.SPSS 26.0 software was used for statistical analy-sis.Chi-square test and Logistic regression analysis were used to study the correlation of anti-phosphati-dylserine/prothrombin antibodies and its IgG or IgM subtypes with unexplained recurrent miscarriages.And the diagnostic sensitivity,specificity,the positive predictive value,the negative predictive value of anti-phosphatidylserine/prothrombin antibodies and its IgG or IgM subtypes in unexplained miscarriages was calculated with four-fold table.Results:Chi-square analysis showed that anti-phosphatidylserine/prothrombin antibodies and its IgM subtypes were correlated with recurrent miscarriages(both P＜0.05),while the IgG subtype was not correlated with recurrent miscarriages(P＞0.05).After adjusting with anticardiolipin antibodies,anti-β2 glycoprotein antibodies,lupus anticoagulants,antinuclear anti-bodies,and age by Logistic regression analysis,anti-phosphatidylserine/prothrombin antibodies were cor-related with unexplained recurrent miscarriages(OR=2.084,95％CI 1.045-4.155,P＜0.05),and anti-phosphatidylserine/prothrombin antibody IgM subtypes were correlated with unexplained recurrent miscarriages(OR=2.368,95％CI 1.187-4.722,P＜0.05).The sensitivity of anti-phosphatidyl-serine/prothrombin antibody in recurrent miscarriage was 65.43％,the specificity was 48.51％,the positive predictive value was 33.76％,and the negative predictive value was 77.78％.In the patients with recurrent miscarriages with negative classical antiphospholipid antibodies,the sensitivity of anti-phosphatidylserine/prothrombin antibody was 59.09％,the specificity was 63.23％,the positive predic-tive value was 40.63％,and the negative predictive value was 78.40％.The sensitivity of the anti-phos-phatidylserine/prothrombin antibody IgM subtype for the diagnosis of recurrent miscarriage was 65.43％,the specificity was 50.99％,the positive predictive value was 34.87％,and the negative predictive value was 78.63％.Conclusion:Anti-phosphatidylserine/prothrombin antibody and IgM subtype antibody are correlated with unexplained recurrent miscarriages in patients with at least one unexplained miscarriage.Whether positive anti-phosphatidylserine/prothrombin antibody or IgM subtype could predict future unex-plained recurrent miscarriages warrants a prospective study.关键词
抗磷脂酰丝氨酸/凝血酶原抗体/复发性流产/灵敏度/特异度/相关性分析Key words
Anti-phosphatidylserine/prothrombin antibodies/Recurrent miscarriages/Sensitivity/Specificity/Correlation分类
医药卫生引用本文复制引用
姚中强,李常虹,李欣艺,郭苇,翟佳羽,刘蕊,魏慧,穆荣..抗磷脂酰丝氨酸/凝血酶原抗体与不明原因复发性流产的相关性分析[J].北京大学学报（医学版）,2023,55(6):1058-1061,4.基金项目
北京大学第三医院院企联合项目(项目编号 CON20210900013)Supported by the Joint Project of the Peking University Third Hospital and the Enterprise(CON20210900013) （项目编号 CON20210900013）
