北京大学学报（医学版）2023，Vol.55Issue(6)：1068-1073,6.DOI:10.19723/j.issn.1671-167X.2023.06.018
北京社区人群促红细胞生成素相关因素及其与10年心血管疾病风险的关系
Related factors of endogenous erythropoietin and its association with 10-year risks of cardiovascular disease in a community-based Chinese study
摘要
Abstract
Objective:To investigate the associated factors of endogenous erythropoietin(EPO)and its association with 10-year risks of atherosclerotic cardiovascular disease in a Chinese community-based general population.Methods:The participants of this study were from an atherosclerosis cohort survey which was established by the Department of Cardiology,Peking University First Hospital in 2011.The cohort survey was performed in the Gucheng and Pingguoyuan communities of Shijingshan district in Beijing,China.The inclusion criteria of this study were:(1)endogenous EPO was measured;(2)health ques-tionnaire data and other clinical data were complete;(3)participatants who had cardiovascular or cere-brovascular diseases(defined as self-reported coronary heart disease,stroke or transient ischemic attack)or anemia or estimated glomerular filtration rate(eGFR)＜60 mL/(min·1.73 m2)at baseline were ex-cluded.Multivariate linear regression model was used to examine the associated factors of endogenous EPO.The participants were grouped into low(＜5％),moderate(5％-10％)and high risk(≥10％)groups,based on predicted 10-year cardiovascular disease risk using the prediction for atherosclerotic car-diovascular disease risk in China(China-PAR)equations.Results:A total of 4 013 participants were included.Mean age of them was(55.9±8.2)years,62.2％(n=2 496)of them were female,and 46.3％(n=1 859),70.9％(n=2 845),21.9％(n=879)had hypertension,dyslipidemia and dia-betes,individually.The average body mass index was(26.1±3.3)kg/m2.The median of EPO level was 12.8(9.3-17.4)IU/L and 25.1％(n=998)were at high 10-years risk of cardiovascular disease.Hemoglobin(β=-0.05,95％CI:-0.07 to-0.04)and eGFR ≥90 mL/(min·1.73 m2)(β=-0.05,95％CI:-0.07 to-0.04)were associated with lower in transformed EPO levels while hypertension(β=0.08,95％CI:0.05 to 0.12)and obesity(β=0.14,95％CI:0.09 to 0.18)were associated with higher in transformed EPO levels in multivariate linear regression analyses.Ten-year car-diovascular disease risks were positively associated with in transformed EPO levels(β=0.07,95％CI:0.05 to 0.09).The participants at moderate and high cardiovascular disease risks had significant higher EPO levels than the low risk group(all P＜0.05).Conclusion:In community-based Beijing popula-tions,endogenous EPO was associated with hemoglobin,renal function,obesity and hypertension.Indi-viduals at high 10-years cardiovascular disease risks have higher endogenous EPO levels.Endogenous EPO may be a potential risk marker of cardiovascular disease.关键词
促红细胞生成素/心血管疾病/风险/高血压/肥胖Key words
Erythropoietin/Cardiovascular disease/Risk/Hypertension/Obesity分类
医药卫生引用本文复制引用
陈楚云,张岩,孙蓬飞,赵静,贾佳,范芳芳,王春燕,李建平,姜一梦,霍勇..北京社区人群促红细胞生成素相关因素及其与10年心血管疾病风险的关系[J].北京大学学报（医学版）,2023,55(6):1068-1073,6.基金项目
国家重点研发计划项目(2017YFC1307704)和北京大学医学部-密歇根大学医学院转化医学与临床研究联合研究所基金(BMU20110177、BMU20160530)Supported by the National Key Research and Development Program of China(2017YFC1307704),and University of Michigan Health System & Peking University Health Science Center Joint Institute Foundation(BMU20110177,BMU20160530) （2017YFC1307704）
