影像科学与光化学2023，Vol.41Issue(6)：320-325,6.DOI:10.7517/issn.1674-0475.230712
术前影像学评分联合肿瘤标志物对肝细胞癌TACE术后预后评估价值的研究
Preoperative Imaging Score Combined with Tumor Marker to Evaluate the Prognosis of Hepatocellular Carcinoma after TACE
夏志颖 1杜福川1
作者信息
- 1. 海南省中医院放射科,海南海口 570203
- 折叠
摘要
Abstract
To evaluate the value of imaging tumor burden score(TBS)combined with serum alpha-fetoprotein(AFP)in the prognosis of hepatocellular carcinoma(HCC)after transarterial chemo-embolization(TACE).Clinical and imaging data of 87 HCC patients who underwent TACE were collected.The TBS scores were calculated from CT-enhanced images.OS was compared between groups using Kaplan-Meier survival curves and log-rank test.The median survival of HCC patients after TACE was 20.5 months,and the mean TBS score was 9.52±3.26.The results showed that the 3-year OS decreased progressively with increasing TBS(P＜0.001);the difference in OS between patients with TBS≤9.9 and TBS＞9.9 was statistically significant(P＜0.001).Patients'pre-TACE AFP levels were moderately negatively correlated with OS(r=-0.519;P＜0.001),and OS was worse in patients with AFP≥400 ng/mL compared with those with AFP＜400 ng/mL(P=0.001).Multifactorial analysis showed that patients with TBS≤9.9 and AFP≥400 ng/mL(HR:5.449;95％CI:1.951-15.217;P=0.01),TBS＞9.9 and AFP＜400 ng/mL(HR:13.576;95％CI:5.873-31.382;P＜0.001)and TBS＞9.9 and AFP≥400 ng/mL(HR:27.854;95％CI:8.950-86.683;P＜0.001)were both independent predictors of OS after TACE in patients with hepatocellular carcinoma,and the OS of patients with TBS≤9.9 and AFP＜400 ng/mL was better than the other three groups(P＜0.05).Therefore,the image-based TBS score combined with AFP level has a high value in the prognosis assessment of HCC patients with TACE.关键词
肝细胞癌/经动脉化疗栓塞术/肿瘤负荷评分/甲胎蛋白Key words
hepatocellular carcinoma/transarterial chemo-embolization/tumor burden score/alpha-fetoprotein引用本文复制引用
夏志颖,杜福川..术前影像学评分联合肿瘤标志物对肝细胞癌TACE术后预后评估价值的研究[J].影像科学与光化学,2023,41(6):320-325,6.
