赣南医学院学报2023，Vol.43Issue(10)：1005-1012,8.DOI:10.3969/j.issn.1001-5779.2023.10.003
黄酮类金属配合物抗肿瘤作用的研究进展
Research progress in antitumor effect of flavonoid metal complexes
摘要
Abstract
Cancer is a major public health problem worldwide,and medication has become one of the most important clinical methods for tumor treatment.Continuous efforts have been made in the investigation of new metallodrugs that are endowed with anticancer property.Flavonoids have drawn considerable attention in the field of metal based anticancer drugs,owing to their excellent coordination properties,DNA binding ability,and potential antitumor bioactivity.Comprehensive studies have demonstrated that the complexation of flavonoids with metals would not only result in the corresponding metallic compounds presenting greater antitumor potency,but also improve their bioavailability and reduce toxic side effects.On this basis,the article intends to review the coordination modes and antitumor properties of the reported flavonoid-metal complexes,according to the characteristics of the mother nucleus structures,such as flavone,flavonol,dihydroflavone,dihydroflavonol,isoflavone,and chalcone,with the aim to provide a theoretical basis for developing related metallic compounds and to promote the application of metallodrugs in the field of cancer therapy.关键词
黄酮/金属配合物/配位模式/抗肿瘤/协同作用Key words
Flavonoids/Metal complex/Coordination mode/Antitumor/Synergistic effect分类
医药卫生引用本文复制引用
李薇,黄艳,王姿秀,邱敏华,叶轶霏,丁萍,李珊,雷健..黄酮类金属配合物抗肿瘤作用的研究进展[J].赣南医学院学报,2023,43(10):1005-1012,8.基金项目
国家自然科学基金项目(22168001) （22168001）
江西省教育厅科学技术研究项目(GJJ201543) （GJJ201543）
江西省大学生创新创业训练计划项目(202010413001,202110413010) （202010413001,202110413010）
