广东药科大学学报2023，Vol.39Issue(6)：92-97,6.DOI:10.16809/j.cnki.2096-3653.2023101103
维A酸脂质体乳膏的制备与质量评价
Preparation and quality evaluation of retinoic acid liposome cream
摘要
Abstract
Objective To prepare retinoic acid liposome cream and evaluate its quality,which will provide new ideas for the application of retinoic acid.Methods Retinoic acid liposomes were prepared by ethanol injection method,and the optimal preparation technology was screened with the encapsulation rate and drug loading as comprehensive evaluation indexes.The retinoic acid liposome cream was prepared by emulsion method.Percutaneous penetration rate of retinoic acid liposome cream and retinoic acid cream was measured by Franz diffusion cell.Results The best preparation technology was as follows:the concentration of phospholipid was 16 mg/mL,the ratio of phospholipid to cholesterol was 5∶1,the ratio of drug to lipid was 1∶40,and the bath temperature was 60℃.The encapsulation rate of liposomes reached 89.44%,the drug loading capacity of liposomes reached 2.19%.The penetration rate of retinoic acid liposome cream was(0.655 8±0.039 1)(μg·h)/cm2,which was higher than that of retinoic acid cream by(0.442 7±0.034 5)(μg·h)/cm2,and the cumulative permeability of retinoic acid liposome cream in 24 hours was(17.18±1.96)μg/cm2,which was higher than that of retinoic acid cream by(8.964 6±0.394 2)μg/cm2.Conclusion The ethanol injection method for preparing retinoic acid liposomes has a simple process and high encapsulation efficiency.The penetration rate and the accumulated permeability of retinoic acid liposome cream are higher than that of retinoic acid cream.关键词
维A酸/脂质体乳膏/包封率/载药量/经皮渗透速率Key words
retinoic acid/liposome cream/encapsulation rate/drug loading capacity/penetration rate分类
医药卫生引用本文复制引用
郑燕燕,颜利,郝吉福,何玉静..维A酸脂质体乳膏的制备与质量评价[J].广东药科大学学报,2023,39(6):92-97,6.基金项目
国家自然科学基金-青年项目(82003677) （82003677）
山东省自然科学基金-青年项目(ZR2020QH352) （ZR2020QH352）
山东第一医科大学本科生研究计划(SRTP)暨大学生创新创业训练计划项目(2022104391584) （SRTP）
