海南医学院学报2023，Vol.29Issue(23)：1794-1800,7.DOI:10.13210/j.cnki.jhmu.20231017.002
甘油三酯葡萄糖指数与非酒精性脂肪性肝病脂肪变程度及肝纤维化的相关性研究
Correlation between the triglyceride glucose index and the degree of steatosis and liver fibrosis in nonalcoholic fatty liver disease
摘要
Abstract
Objective:To investigate the relationship between triglyceride glucose index(TyG)and the degree of steatosis and liver fibrosis in patients with nonalcoholic fatty liver disease(NAFLD).Methods:Totally 2 054 patients hospitalized in the second affiliated hospital of Xinjiang Medical University from September 2020 to September 2021 were retrospectively selected.According to abdominal ultrasound were divided into NAFLD group and non-NAFLD group.In accordance with the degree of ste-atosis,NAFLD patients were separated into mild group,moderate group and severe group.According to the liver stiffness,NAFLD patients were divided into liver fibrosis group and non-liver fibrosis group.We used the logistic regression to examine the correlation between TyG index and the the degree of steatosis and liver fibrosis.ROC curve was drawn to evaluate the diagnostic value of TyG index for NAFLD and liver fibrosis.Results:The prevalence of NAFLD increased with the increase of the interquar-tile of TyG index(Q1 44.1%,Q2 58.7%,Q3 71.9%,Q4 84.6%,P<0.001);The prevalence of liver fibrosis increased with the in-crease of the interquartile of TyG index(Q1 25.8%,Q2 30.2%,Q3 38.6%,Q4 44.3%,P<0.001).After adjusting for confounders,there was a correlation between TyG index and the degree of steatosis in NAFLD patients(the OR values of mild,moderate and severe groups were 1.383,2.450 and 3.070,P<0.001).TyG index was associated with liver fibrosis(OR=1.132,P<0.001).The ROC curve of TyG index predicted NAFLD was 0.701,with an optimal cutoff of 8.57.However,the ROC curve of TyG in-dex predicted liver fibrosis was 0.595.TyG index may not be a reliable predictor of liver fibrosis.Conclusion:TyG index was posi-tively correlated with the degree of steatosis and liver fibrosis in NAFLD.关键词
甘油三酯葡萄糖指数/非酒精性脂肪性肝病/脂肪变/肝纤维化Key words
Triglyceride glucose index/Non-alcoholic fatty liver disease/Steatosis/Liver fibrosis分类
医药卫生引用本文复制引用
努尔吉马·阿合尼牙孜,刘一佳,梁灿灿,丁永年..甘油三酯葡萄糖指数与非酒精性脂肪性肝病脂肪变程度及肝纤维化的相关性研究[J].海南医学院学报,2023,29(23):1794-1800,7.基金项目
This study was supported by Natural Science Foundation of Xinjiang Uygur Autonomous Region(2021D01C356) （2021D01C356）
Open Project of the State Key Laboratory of Co-Construction of Causes and Prevention of High Morbidity in Central Asia(SKL-HIDCA-2021-EF2) 新疆维吾尔自治区自然科学基金(2021D01C356) （SKL-HIDCA-2021-EF2）
省部共建中亚高发病成因与防治国家重点实验室开放课题(SKL-HIDCA-2021-EF2) （SKL-HIDCA-2021-EF2）
