海南医学院学报2023，Vol.29Issue(23)：1825-1830,1835,7.DOI:10.13210/j.cnki.jhmu.20230310.001
1-磷酸鞘氨醇及其信号传导在中枢神经系统疾病中的研究进展
Research progress of sphingosine 1-phosphate and its signal transduction in central nervous system diseases
摘要
Abstract
Sphingosine 1-phosphate(S1P),as a sphingolipid metabolite,has become a key substance in regulating vari-ous physiological processes,involved in differentiation,proliferation,migration,morphogenesis,cytoskeleton formation,adhe-sion,and apoptosis process.Sphingosine 1-phosphate can not only activate the S1P-S1PR signaling pathway by binding to the cor-responding receptors on the cell membrane,but also play a role in the cell.In recent years,studies have found that there is a cer-tain relationship between its level changes and the occurrence and development of central nervous system diseases.This article re-views the latest knowledge of sphingosine-1-phosphate in the occurrence and treatment of nervous system diseases,and further clarifies its molecular mechanism in the treatment and development of central nervous system diseases.关键词
1-磷酸鞘氨醇/鞘脂代谢/中枢神经系统疾病/鞘氨醇激酶/S1P受体Key words
Sphingosine 1-phosphate/Sphingolipid metabolism/Central nervous system diseases/Sphingosine kinase/S1P receptor分类
医药卫生引用本文复制引用
贲新宇,易西南,李其富..1-磷酸鞘氨醇及其信号传导在中枢神经系统疾病中的研究进展[J].海南医学院学报,2023,29(23):1825-1830,1835,7.基金项目
This study was supported by the National Natural Science Foundation of China(82260270) （82260270）
Hainan Clinical Medical Center(2021) （2021）
Innovation Team for Epilepsy Research at Hainan Medical College(2022) 国家自然科学基金资助项目(82260270) （2022）
海南省临床医学中心(2021)资助 （2021）
海南医学院癫痫研究创新团队(2022)资助 （2022）
