海南医学院学报2023，Vol.29Issue(23)：1831-1835,5.DOI:10.13210/j.cnki.jhmu.20221229.001
ICOSL/ICOS在母胎免疫耐受中的研究进展
Research progress of ICOSL/ICOS pathway in maternal-fetal immune tolerance
摘要
Abstract
Co-signaling molecules are molecules whose ligands on the surface of cells interact with receptors on the surface of T cells to convey stimulatory or inhibitory signals to regulate immune responses.Co-signaling molecules play an important role in tumor and autoimmune diseases.Lately,studies have shown that co-signaling molecules are also involved in the regulation of maternal-fetal immune tolerance,and abnormalities of co-signaling molecules may lead to the imbalance of maternal-fetal immune tolerance,resulting in recurrent abortion,eclampsia and other pregnancy complications.ICOSL/ICOS is a ligand and receptor of costimulatory signals,which regulates maternal and fetal immune tolerance by participating in T cell differentiation and Th1 and Th2 cytokine secretion.Therefore,this article reviews the structure of ICOSL/ICOS,the distribution of ICOSL/ICOS at the maternal-fetal interface and its immune regulation during pregnancy,in order to provide new ideas for the future study of immuno-therapy of pregnancy complications caused by abnormal co-signaling molecules.关键词
共刺激分子/ICOSL/ICOS/免疫耐受/Th1、Th2Key words
Co-stimulatory molecules/ICOSL/ICOS/Immune tolerance/Th1/Th2分类
医药卫生引用本文复制引用
梅娇琪,杨晓惠,李蒙勇威,马燕琳,黄元华..ICOSL/ICOS在母胎免疫耐受中的研究进展[J].海南医学院学报,2023,29(23):1831-1835,5.基金项目
This study was supported by National Natural Science Foundation of China(81960283,82072880) 国家自然科学基金(81960283、82072880) （81960283,82072880）
