郑州大学学报（医学版）2023，Vol.58Issue(6)：836-840,5.DOI:10.13705/j.issn.1671-6825.2022.12.064
双相情感障碍共病代谢综合征的危险因素及临床药师干预模式的效果
Analysis of risk factors for bipolar disorder comorbid with metabolic syn-drome and efficacy of clinical pharmacist intervention mode
摘要
Abstract
Aim:To investigate the risk factors for bipolar disorder comorbid with metabolic syndrome(MS)and the ef-ficacy of clinical pharmacist intervention mode.Methods:Sixty cases of bipolar disorder comorbid with MS treated in the hospital from April to September,2022 were selected(MS group).Sixty cases of bipolar disorder without MS during the same period were matched(non-MS group).The baseline indicators of the 2 groups were compared,and the indicators with differences between the 2 groups were included in the Logistic regression model to analyze the risk factors for bipolar disor-der comorbid with MS.The cases in the MS group were allocated into study group and control group according to the random number table method,with 30 in each group.In addition to the conventional treatment,the control group adopted convention-al nursing intervention mode,and the study group was given clinical pharmacist intervention mode based on the conventional nursing intervention.The metabolic indexes(triglycerides,BMI,fasting blood glucose)before intervention,at 3 and 6 months intervention as well as the differences of various scores[Young's Mania Rating Scale(YMRS),Hamilton Depression Scale(HAMD),Social Functioning Deficits Screening Scale(SDSS),and Wisconsin Card Sorting Test(WCST)]before interven-tion and at 6 months intervention between the study group and control group were compared.Results:Logistic regression a-nalysis showed that high BMI,a family history of diabetes mellitus,more medication types,and longer total duration of medi-cation were risk factors for bipolar disorder comorbid with MS[OR(95%CI)was 1.244(1.135-1.363),19.667(2.504-154.470),5.859(2.820-12.171)and 2.256(1.651-3.083)].After 3 and 6 months intervention,triglyceride,BMI,and fasting blood glucose levels were reduced in the study group and control group,with the reduction in triglyceride levels being more significant in the study group;the differences in YMRS score,HAMD score,SDSS score,and WCST score before and after 6 months intervention were higher in the study group than those in control group(P<0.05).Conclusion:High BMI,a family history of diabetes mellitus,more medication types,and longer total duration of medication are risk factors af-fecting bipolar disorder comorbid with MS;the clinical pharmacist intervention mode could improve metabolic indexes and promote the recovery of various functions in cases of bipolar disorder comorbid with MS.关键词
双相情感障碍/代谢综合征/危险因素/临床药师/干预模式Key words
bipolar disorder/metabolic syndrome/risk factor/clinical pharmacist/intervention mode分类
医药卫生引用本文复制引用
蔡向明,葛振华,葛雨忻,孙晓宇,罗勇华,耿建峰,杨蕾..双相情感障碍共病代谢综合征的危险因素及临床药师干预模式的效果[J].郑州大学学报（医学版）,2023,58(6):836-840,5.基金项目
南通市卫生健康委员会面上科研项目(MB2021064) （MB2021064）
江苏省药学会-天晴医院药学基金项目(Q202132) （Q202132）
