郑州大学学报（医学版）2023，Vol.58Issue(6)：841-847,7.DOI:10.13705/j.issn.1671-6825.2023.03.025
基于电子射野影像装置的肺部肿瘤立体定向体部放射治疗在体三维剂量验证模体研究及临床应用
Study on phantom testing and clinical application of lung tumor SBRT based on EPID-based in-vivo 3 D dose verification system
摘要
Abstract
Aim:To evaluate different irradiation treatment plans using an in-vivo 3D dose verification system based on the electronic portal imaging device(EPID)using phantom,and clinical application of stereotactic body radiation therapy(SBRT).Methods:The study utilized two types of phantoms(static and dynamic phantoms).An in-vivo 3D dose verifica-tion system based on EPID was employed to capture images of various irradiation planning techniques,including static inten-sity-modulated radiotherapy(sIMRT),dynamic intensity-modulated radiotherapy(dIMRT),volumetric modulated arc thera-py(VMAT),conventional radiotherapy(CRT),and dynamic conventional arc therapy(Dynarc).Gamma passing rate was compared under different dose/distance tolerance for various conditions(5%/2 mm,3%/3 mm,3%/2 mm,3%/1 mm,2%/2 mm).In clinical cases,dose-volume histograms were utilized to analyze the dose distribution of the target volume and organs at risk(OARs).Results:In the static phantoms,there were no significant differences in the gamma passing rate be-tween VMAT,sIMRT and dIMRT.However,in the dynamic phantoms,the gamma passing rate of the sIMRT plan was lower compared with other delivery methods.For clinical cases,the gamma passing rate for in-vivo 3D dose verification(3%/3 mm)was still considerably lower than that of pretreatment.In dose volume histogram analysis,OARs with significant volume changes exhibited considerable dose deviations.Conclusions:The implementation of this procedure can enhance SBRT pa-tients'safety,and serve as a preliminary step towards clinical adaptive radiotherapy.关键词
肺部肿瘤/电子射野影像装置/立体定向体部放射治疗/在体三维剂量验证/γ通过率Key words
lung tumor/electronic portal imaging device/stereotactic body radiation therapy/in-vivo 3D dose verifica-tion/gamma passing rate分类
医药卫生引用本文复制引用
王鹏飞,刘晓,毛荣虎,李兵,郭伟,王保胜,葛红,雷宏昌,王祥..基于电子射野影像装置的肺部肿瘤立体定向体部放射治疗在体三维剂量验证模体研究及临床应用[J].郑州大学学报（医学版）,2023,58(6):841-847,7.基金项目
河南省科技攻关计划项目(222102310322) （222102310322）
