哈尔滨商业大学学报（自然科学版）2023，Vol.39Issue(6)：653-660,8.
五加五味软胶囊研制与质量评价
Study on preparation technology and quality evaluation of Acanthopanax senticosus and Schisandra chinensis soft capsule
摘要
Abstract
The preparation technology of Acanthopanax senticosus and Schisandra chinensis soft capsule was studied and its quality was evaluated.The best prescription was selected with matrix,particle size of drug powder,suspending agent,co-solvent and other auxiliary materials as single factor,capsule yield and capsule ligation phenomenon as evaluation index,and factors such as feed port,temperature and rotational speed of soft capsule machine were investigated.Orthogonal test was used to screen the preparation process,and the product quality evaluation was studied.The results showed that soybean oil was used as the content matrix,the powder was sifted through 100 mesh,the dosage of beeswax was 4%,the dosage of cosolvent Tween-80 was 0.5%,and the ratio of gelatin∶glycerin∶purified water was 1.0∶0.35∶1.0,and stood for 24 hours.The preparation conditions were as follows:feed temperature 50℃,rotational speed ratio 1.75,drying time 6 h.The shell color of the prepared Acanthopanax senticosus soft capsules was light yellow,and the contents were yellow.The soft capsules were all intact and clean,without adhesion,deformation,leakage,and occasional damage of the capsule shell.The limit of load difference was±10%,and the disintegration time was less than 60 min.The average contents of Schisandrin,deoxyschisandrin and γ-Schisandrin and syringin were(3.657±0.027)mg/g,(0.563±0.005)mg/g,(1.666±0.012)mg/g and(1.418±0.008)mg/g,respectively.The quality of the soft capsule obtained by this preparation process was stable and controllable,which was beneficial to give full play to the synergistic effect of the two drugs,and has a broad market prospect.关键词
刺五加总苷/五味子总木脂素/软胶囊/正交设计/制剂工艺/质量评价Key words
Acanthopanax senticosus total glycosides/total lignans of Schisandra chinensis/soft capsule/orthogonal design/preparation process/quality evaluation分类
医药卫生引用本文复制引用
赵俊毅,陈鹰翔,韩继鹏,曲中原,邹翔..五加五味软胶囊研制与质量评价[J].哈尔滨商业大学学报（自然科学版）,2023,39(6):653-660,8.基金项目
黑龙江省博士后科研启动金资助项目(LBH-Q16133) （LBH-Q16133）
黑龙江省教育厅基础科研业务费项目(2020CX48) （2020CX48）
