江汉大学学报（自然科学版）2023，Vol.51Issue(6)：33-39,7.DOI:10.16389/j.cnki.cn42-1737/n.2023.06.005
沙库巴曲缬沙坦对合并高血压的急性心肌梗死PCI术后患者的疗效分析
Efficacy Analysis of Sacubitril/Valsartan in Patients with Acute Myocardial Infarction Complicated with Hypertension After PCI
张唐莉 1刘慧地 2刘波 2张苏川2
作者信息
- 1. 江汉大学医学部,湖北 武汉 430056||江汉大学附属医院心血管内科,湖北 武汉 430015
- 2. 江汉大学附属医院心血管内科,湖北 武汉 430015
- 折叠
摘要
Abstract
Objective To investigate the clinical efficacy and safety of sacubitril valsartan(ARNI)in the treatment of patients with acute myocardial infarction(AMI)complicated with hypertension after percutaneous coronary intervention(PCI).Methods A total of 124 patients with AMI complicated with hypertension after PCI in 24 hours from October 2020 to April 2022 in the Affiliated Hospital of Jianghan University were selected and divided into the study group and the control groups according to the random principle.64 cases were treated with maximum tolerable dose of ARNI as the study group,while 60 cases were treated with valsartan as the control group,with a follow-up for 26 weeks.The changes in left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),N-terminal pro-B-type natriuretic peptide(NT-proBNP),mean systolic blood pressure(SBP),mean diastolic blood pressure(DBP)and mean heart rate(HR)before and after the treatment were compared between the two groups.The rates of adverse cardiovascular events and drug adverse reactions were observed during follow-up.Results① LVEDD,NT-ProBNP,the mean SBP,and the mean DBP significantly decreased,and LVEF significantly increased in both groups after the treatment(P<0.05 for all comparisons).② LVEDD,NT-ProBNP,and the mean SBP were significantly lower,and LVEF was evidently higher in the study group than in the control group after the treatment(P<0.05 for all comparisons).③ There was no difference in the incidence of adverse reactions and major cardiovascular adverse events between the two groups(P>0.05 for all comparisons).Conclusion ARNI is superior and safe to valsartan in improving left ventricular remodeling,protecting cardiac function,and reducing SBP in patients with AMI complicated with hypertension after PCI.关键词
沙库巴曲缬沙坦/急性心肌梗死/高血压/心室重构/心功能Key words
sacubitril/valsartan/acute myocardial infarction/hypertension/ventricular remodeling/cardiac function分类
医药卫生引用本文复制引用
张唐莉,刘慧地,刘波,张苏川..沙库巴曲缬沙坦对合并高血压的急性心肌梗死PCI术后患者的疗效分析[J].江汉大学学报（自然科学版）,2023,51(6):33-39,7.
