结核与肺部疾病杂志2023，Vol.4Issue(6)：475-479,5.DOI:10.19983/j.issn.2096-8493.20230099
2020-2022年重庆市耐多药结核病患者氟喹诺酮类药物耐药情况及影响因素分析
Analysis of fluoroquinolones resistance in multidrug-resistant tuberculosis patients in Chongqing from 2020 to 2022
摘要
Abstract
Objective:To analyze the resistance of multidrug-resistant tuberculosis(MDR-TB)patients to fluoroquinolones(FQs)and its influencing factors in Chongqing.Methods:A simple random sampling method was used in 165 MDR-TB patients from 39 districts(counties)in Chongqing from January 2020 to December 2022(study subjects),and basic information of the study subjects was collected.All the 165 strains of multidrug-resistant Mycobacterium tuberculosis(MDR-MTB)isolated from the study subjects were confirmed through strain identification and proportional drug sensitivity testing.Using the micro broth dilution method,the drug sensitivities of clinical isolates to ofloxacin(Ofx),levofloxacin(Lfx),and moxifloxacin(Mfx)were tested,and the drug resistance of the strains to FQs and related influencing factors were analyzed.Results:The total resistance rate of 165 MDR-MTB isolates to FQs was 37.6％(62/165),and the resistance rates to Ofx,Lfx,and Mfx were 37.6％(62/165),37.0％(61/165),and 29.7％(49/165),respectively.Multivariate logistic regression analysis showed that no history of FQs medication was a protective factor for FQs resistance(OR(95％CI)=0.348(0.169-0.717)).Conclusion:The FQs resistance rate of MDR-TB patients in Chongqing is relatively high,and patients with a history of FQs medication have a higher risk of FQs resistance.关键词
分枝杆菌,结核/喹诺酮类/抗药性,多药/危险因素Key words
Mycobacterium tuberculosis/Quinolones/Drug resistance,multiple/Risk factors分类
医药卫生引用本文复制引用
游国庆,刘文果,冯鑫,余敏,石林,胡彦..2020-2022年重庆市耐多药结核病患者氟喹诺酮类药物耐药情况及影响因素分析[J].结核与肺部疾病杂志,2023,4(6):475-479,5.基金项目
Chongqing Science and Health Joint Medical Research Project(2022MSXM102,2022MSXM066) （2022MSXM102,2022MSXM066）
The First Batch of Key Public Health Disciplines(Junior Colleges)in Chongqing((2022)72)重庆市科卫联合医学科研项目(2022MSXM102,2022MSXM066) （Junior Colleges）
重庆市首批公共卫生重点学科(专科)([2022]72) （专科）
