结核与肺部疾病杂志2023，Vol.4Issue(6)：511-518,8.DOI:10.19983/j.issn.2096-8493.20230108
白细胞介素-1在巨噬细胞抗结核分枝杆菌免疫应答及代谢重编程的作用研究进展
Research progress on the role of interleukin-1 in immune response and metabolic reprogramming of macrophages against Mycobacterium tuberculosis
摘要
Abstract
Tuberculosis caused by Mycobacterium tuberculosis(MTB),remains an important chronic inflammatory respiratory infectious disease.The pathogenesis of MTB depends on its ability to regulate the host metabolism.The host macrophage metabolic plasticity plays a key role in the progress of tuberculosis.The host release of IL-1 during MTB infection is critical for host defence and is subject to the host metabolic status.We reviewed the secretion of IL-1 during MTB infection and its effect on host resistance,the regulation of IL-1 by host macrophage metabolic reprogramming,and the crosstalk between IL-1 and other cytokines.This can deepen our understanding of host resistance to infection and the role of IL-1.关键词
分枝杆菌,结核/白细胞介素1/巨噬细胞/代谢重编程Key words
Mycobacterium tuberculosis/Interleukin-1/Macrophage/Metabolic reprogramming分类
医药卫生引用本文复制引用
闫亚如,谢建平..白细胞介素-1在巨噬细胞抗结核分枝杆菌免疫应答及代谢重编程的作用研究进展[J].结核与肺部疾病杂志,2023,4(6):511-518,8.基金项目
National Natural Science Fundation of China(82211530059)国家自然科学基金(82211530059) （82211530059）
