实用临床医药杂志2023，Vol.27Issue(22)：24-30,7.DOI:10.7619/jcmp.20232767
可注射藻蓝蛋白纳米复合水凝胶的制备及其对伤口愈合效果研究
Research of preparation of injectable phycocyanin nanocomposite hydrogels and its application effect in wound healing
龙金华 1廖影 2滕丽晶 2曾柱2
作者信息
- 1. 贵州医科大学附属肿瘤医院头颈肿瘤科,贵州贵阳,550004
- 2. 贵州医科大学生物与工程学院/基础医学院,贵州贵阳,550025
- 折叠
摘要
Abstract
Objective To investigate the effect of preparation of shear-thinning CPC/LP nano-composite hydrogel for wound healing by supramolecular interaction of polydopamine(LP)and phy-cocyanin(CPC)based on nano-clayoxidation.Methods LP aggregates were formed by polymeriza-tion of dopamine monomers in weak alkaline oxygen-containing environment of nano-clay dispersion,and then mixed it with multifunctional CPC to form shear-thinning nanocomposite hydrogels by electro-static action and Schiff base.The microstructure,rheological properties,blood compatibility and wound healing effect of hydrogel were studied systematically.Results The gelation performance of CPC/LP nanocomposite hydrogel was related to LP content.When LP content was 3％and CPC con-tent was 0.5％,stable gel could be formed;rheological test results showed that the nanocomposite hydrogel had the properties of shear thinning and self-healing;the results of blood compatibility test showed that the hemolysis rate of the nanocomposite hydrogel was less than 5％,and it had good blood compatibility.In addition,the nanocomposite hydrogel could be injected into the injury site through a smaller needle to promote wound healing.Conclusion CPC/LP nanocomposite hydrogel exhibits excellent injectable properties and can effectively promote wound healing.关键词
水凝胶/纳米黏土/聚多巴胺/藻蓝蛋白/剪切变稀/伤口愈合Key words
hydrogel/nano-clay/polydopamine/phycocyanin/shear-thinning/wound healing分类
医药卫生引用本文复制引用
龙金华,廖影,滕丽晶,曾柱..可注射藻蓝蛋白纳米复合水凝胶的制备及其对伤口愈合效果研究[J].实用临床医药杂志,2023,27(22):24-30,7.
