实用临床医药杂志2023，Vol.27Issue(22)：86-89,94,5.DOI:10.7619/jcmp.20232964
利培酮联合氯氮平治疗流浪精神分裂症患者的效果观察
Efficacy of risperidone combined with clozapine in the treatment of vagrants with schizophrenia
摘要
Abstract
Objective To observe the effect of risperidone combined with clozapine in the treatment of vagrants with schizophrenia and its influence on social function of the patients.Methods Eighty patients with vagrant schizophrenia were selected as the study objects by a prospective randomized controlled trial,and were randomly divided into control group(40 cases)and observation group(40 cases).The control group was treated with risperidone,and the observation group was treated with risperidone and clozapine.Both groups received continuous treatment for 8 weeks.The clinical effects of the two groups were observed.The activities of daily living,rehabilitation[Inpatient Psychiatric Rehabilitation Efficacy Rating Scale(IPROS)score],social function,myocardial enzyme profile[lactate dehydrogenase(LDH),creatine kinase(CK),creatine kinase isoenzyme(CK-MB)]in the two groups before treatment and eight weeks after treatment were compared.The adverse reactions of the two groups were statistically analyzed.Results The total effective rate of treatment in the obser-vation group was higher than that of the control group(90.00％versus 72.50％,P＜0.05).After eight weeks of treatment,the abilities of daily living and social function of the two groups were stron-ger than before treatment,and the observation group was stronger than the control group.At 8 weeks of treatment,IPROS scores in two groups were lower than before treatment,and observation group was lower than control group(P＜0.05).After 8 weeks of treatment,LDH,CK and CK-MB levels in two groups were higher than before treatment(P＜0.05),but there was no statistical significant between-group difference(P＞0.05).Conclusion Risperidone combined with clozapine has a significant effect in thetreatment of vagrants with schizophrenia,which can enhance the patients'daily living ability and social ability,improve the rehabilitation status,and does not increase the adverse reactions.关键词
精神分裂症/利培酮/氯氮平/心肌酶谱/生活能力/社会功能Key words
schizophrenia/risperidone/clozapine/myocardial enzyme profile/ability to live/social function分类
医药卫生引用本文复制引用
赵天真,庞堃,王晓华,巨星,胡岳..利培酮联合氯氮平治疗流浪精神分裂症患者的效果观察[J].实用临床医药杂志,2023,27(22):86-89,94,5.基金项目
河北省卫生健康委科研基金项目青年科技课题(20211460) （20211460）
