实用临床医药杂志2023，Vol.27Issue(22)：114-117,122,5.DOI:10.7619/jcmp.20232943
丹参多酚酸盐联合依达拉奉对急性脑梗死患者认知、脑动脉搏动指数及血清视锥蛋白样蛋白-1水平的影响
Effects of Danshen polyphenolate combined with edaravone on cognition,cerebral artery pulse index and serum visinin like protein-1 levels in patients with acute cerebral infarction
摘要
Abstract
Objective To investigate the effects of Danshen polyphenolate combined with edara-vone on cognitive function,cerebral artery pulse index(PIMCA)and serum trypanoprotein-like pro-tein-1(VILIP-1)levels in patients with acute cerebral infarction(ACI).Methods A total of 88 pa-tients with ACI were selected as study objects.The patients were divided into single drug group(n=44)and combination group(n=44)according to random number table method.The single drug group was treated with edaravone,and the combination group was treated with edaravone combined with salvianolic acid for injection.The efficacy,cognitive function,PIMCA and serum VILIP-1 levels of the two groups were observed and compared.Results The overall effective rate of treatment in the combi-nation group was higher than that of the single drug group(81.82％versus 54.55％,P＜0.05).Af-ter treatment,the scores of Montreal Cognitive Assessment Scale(MoCA),Reactivity Exploration Scale(RSS)and Simple Mental State Assessment Scale(MMSE)in two groups were higher than be-fore treatment,and the combination group was higher than the single drug group(P＜0.05).After treatment,the levels of PIMCA and serum VILIP-1 in two groups were lower than before treatment,and the combination group was lower than the single drug group(P＜0.05).Conclusion Compared with edaravone alone,salvia miltiorrhiza polyphenolate injection combined with edaravone has a better therapeutic effect in ACI patients,which can effectively improve the patients'cognition,reduce PIMCA and serum VILIP-1 levels.关键词
丹参多酚酸盐/依达拉奉/急性脑梗死/认知功能/脑动脉搏动指数/视锥蛋白样蛋白-1Key words
Danshen polyphenolate/edaravone/acute cerebral infarction/cognitive func-tion/cerebral artery pulsation index/visinin-like protein-1分类
医药卫生引用本文复制引用
齐赛卿,张亚伟,李君朝,申志国..丹参多酚酸盐联合依达拉奉对急性脑梗死患者认知、脑动脉搏动指数及血清视锥蛋白样蛋白-1水平的影响[J].实用临床医药杂志,2023,27(22):114-117,122,5.基金项目
河北省邯郸市科学技术研究与发展计划项目(22422083093ZC) （22422083093ZC）
