实用临床医药杂志2023，Vol.27Issue(22)：118-122,5.DOI:10.7619/jcmp.20232675
成人癫痫患者服药依从性个体化预测模型的建立与验证
Establishment and validation of an individualized predictive model for medication compliance in epilepsy adult patients
摘要
Abstract
Objective To establish an individualized prediction model for medication compli-ance in epilepsy adult patients and verify its predictive effect.Methods A total of 192 epilepsy pa-tients were selected as study objects,the Morisky Medication Adherence Scale(MMAS)was applied to assess patients'medication compliance,and patients were divided into compliance group(MMAS score of 6 to 8 points)and control group(MMAS score＜6 points)based on their compliance status.The general information,disease information,medication information,and social support of patients were analyzed.Multiple Logistic regression analysis was applied to analyze the influencing factors of pa-tients'medication compliance,the rms program package in R software was applied to establish a column chart model for predicting medication adherence,and the area(AUC)under the receiver operating characteristic(ROC)curve and the calibration curve were used to test its discrimination and accuracy.Results Among the 192 patients,119(61.98％)had good medication adherence and 73(38.02％)had poor medication adherence.The main influencing factors of medication compliance in epilepsy patients included educational background,antiepileptic drug medication type,side effects of drugs,frequency of medication knowledge education,and social support(P＜0.05);a column chart model for medication compliance in epilepsy patients was constructed based on five predictive indicators,the results showed that the AUC was 0.830(95％CI,0.772 to 0.888),and the calibration curve and ideal curve trends were similar,the goodness of fit Hosmer-Lemeshow test showed that thechi-square value was 9.970 and P value was 0.267,indicating that the model had high discrimination and accu-racy.Conclusion The nomogram established based on educational background,administration of antiepileptic drug type,side effects of drugs,frequency of medication knowledge education,and social support has a good predictive value in medication compliance in epilepsy patients.关键词
癫痫/服药依从性/列线图模型/药物副作用/社会支持Key words
epilepsy/medication compliance/nomogram model/drug side effects/social support分类
医药卫生引用本文复制引用
陈文静,席从林,宋静..成人癫痫患者服药依从性个体化预测模型的建立与验证[J].实用临床医药杂志,2023,27(22):118-122,5.基金项目
江苏省卫生健康委医学科研项目(Z2019060) （Z2019060）
