实用临床医药杂志2023，Vol.27Issue(22)：131-137,7.DOI:10.7619/jcmp.20232163
利多卡因治疗癌性疼痛研究进展
Research progress of lidocaine in the treatment of cancer pain
摘要
Abstract
Pain permeates the entire process of cancer,and its mechanism is complex,involving tumor microenvironment,cancer-related bone pain,cancer-related visceral pain,cancer-related neuro-pathic pain,and surgery and radiotherapy-related factors.Studies have indicated that lidocaine can al-leviate intractable cancer pain for opioids,and its mechanism of action in treating various types of cancer pain may also be different,involving the regulation of acid-sensing ion channels(ASICS),transient receptor potential channels(TRP),voltage-gated sodium channels(VGSCs),nerve growth factor(NGF),glutamate and its receptors,inflammatory cells and cytokines,microglia,astrocytes,and high mobility group box 1 protein(HMGB1).This paper reviewed the mechanisms of cancer pain,the mechanisms of lidocaine in treating different types of cancer pain as well as its clinical appli-cations.关键词
癌痛/癌痛类型/机制/利多卡因/阿片类药物Key words
cancer pain/types of cancer pain/mechanism/lidocaine/opioids分类
医药卫生引用本文复制引用
朱开润,解成兰,杨晓倩,金文杰..利多卡因治疗癌性疼痛研究进展[J].实用临床医药杂志,2023,27(22):131-137,7.基金项目
江苏省重点实验室开放课题资助项目(XZSYSKF2020039) （XZSYSKF2020039）
2020年度江苏省卫生健康委科研项目(Z2020080) （Z2020080）
