生物灾害科学2023，Vol.46Issue(4)：538-548,11.DOI:10.3969/j.issn.2095-3704.2023.04.79
5类有毒动物毒液金属蛋白酶研究进展
Research Progress on Venom Metalloproteinases of Five Types of Poison-carrying Animals
摘要
Abstract
Metalloproteinases are commonly found in organisms such as animals,plants and bacteria,and it is worth noting that metalloproteinases are retained in the venom of snakes,scorpions,parasitic wasps,jellyfishes,and spider,and participate in physiological processes,and play important roles in their predation,defense and digestion.This paper summarized the classification of metalloprotease families,which are divided into 74 families in 17 groups.Researches on the sequence structure,family classification,biological activity and functional mechanism of metalloproteinases of these five types of poison-carrying animals were comprehensively described.It was found that metalloproteases of M10 family existed in the venom of parasitic wasps and jellyfishes,that of M13 family existed in the venom of parasitic wasps and scorpions,M12 family were commonly found in the venom of snakes,parasitic wasps,scorpions and jellyfishes.Researches of snake venom metalloproteinases were relatively deep and comprehensive,which had the activities and functions of degrading extracellular matrix proteins,regulating cells,inhibiting platelet aggregation and so on.The studies of venom metalloproteinases in scorpions,parasitic wasps,spiders and jellyfishes were relatively less,and their molecular structure,family classification,function and mechanism of action,were still unclear.The article can deepen scholars'understanding of venom metalloproteinases,and provide references for the future research direction of venom metalloproteinases,and lay the foundation for the application of venom metalloproteinases.关键词
毒液金属蛋白酶/家族分类/生物活性/功能机制/研究Key words
venom metalloproteinases/family classification/bioactivity/functional mechanism/research分类
生物科学引用本文复制引用
徐志文,任雪敏,吴朝妍,雷林..5类有毒动物毒液金属蛋白酶研究进展[J].生物灾害科学,2023,46(4):538-548,11.基金项目
贵州省林业科研项目(黔林科合J字[2022]30号)和中央引导地方科技发展资金项目(黔科中引地[2019]4004号) （黔林科合J字[2022]30号）
