解放军医学院学报2023，Vol.44Issue(9)：956-960,978,6.DOI:10.12435/j.issn.2095-5227.2023.033
中老年男性人群高胆固醇血症与小肠细菌过度生长的关系探讨
Association between hypercholesterolemia and small intestinal bacterial overgrowth in middle-aged and elderly men
摘要
Abstract
Background Intestinal bacterial overgrowth(SIBO)is the pathological growth of the gut microbiota of the small intestine.Recent studies have shown that hypercholesterolemia is associated with alterations in gut microbiota.However,the association between hypercholesterolemia and SIBO is poorly understood.Objective To investigate the association between hypercholesterolemia and SIBO in middle-aged and elderly men.Methods Male patients aged≥50 years old who visited the Outpatient Department of Gastroenterology of the Second Medical Center of Chinese PLA General Hospital from October 2018 to October 2019 were enrolled.Subjects were divided into the SIBO(+)and SIBO(-)groups.Multivariate binary logistic regression model was used to evaluate the association between hypercholesterolemia and SIBO.Results A total of 237 subjects were enrolled,including 50 subjects with hypercholesterolemia(prevalence 21.1%)and 166 subjects with SIBO(prevalence 70.04%).The proportion of hypercholesterolemia and history of gastroenterectomy in SIBO(+)group was higher than that in SIBO(-)group(P＜0.05).Multivariate logistic regression showed that after adjusting for age,BMI,history of gastrointestinal surgery,and serum levels of albumin,total protein and glutamyl transpeptidase,the incidence of SIBO in patients with hypercholesterolemia was 2.397 times of that in those with normal cholesterol(95%CI:1.034-5.558).Conclusion Hypercholesterolemia is positively associated with SIBO in middle-aged and elderly men with non-organic gastrointestinal disease in the outpatient department of gastroenterology.关键词
小肠细菌过度生长/高胆固醇血症/肠道菌群/老年男性/消化疾病Key words
small intestinal bacterial overgrowth/hypercholesterolemia/gut microbiota/elderly men/digestive disease分类
医药卫生引用本文复制引用
李佳,唐帅,马金霞,朱文娅,李毅,廖涵,万军..中老年男性人群高胆固醇血症与小肠细菌过度生长的关系探讨[J].解放军医学院学报,2023,44(9):956-960,978,6.基金项目
军委后勤保障部专项课题(17BJZ46) （17BJZ46）
