解放军医学院学报2023，Vol.44Issue(9)：961-965,972,6.DOI:10.12435/j.issn.2095-5227.2023.028
Ⅰ期PR阳性低级别子宫内膜间质肉瘤患者术后激素治疗的预后及相关因素分析
Clinical outcomes of postoperative hormonal treatment in patients with low-grade endometrial stromal sarcoma at stage Ⅰ and its related factors
叶艳箐 1文亮 1李明霞 2孟元光 2叶明侠2
作者信息
- 1. 解放军医学院,北京 100853||解放军总医院第一医学中心妇产科,北京 100853
- 2. 解放军总医院第一医学中心妇产科,北京 100853
- 折叠
摘要
Abstract
Background Low-grade endometrial stromal sarcoma(LGESS)is a rare gynecological malignancy.For LGESS patients at stage Ⅰ,the value of postoperative adjuvant treatment on its prognosis is inconclusive.At present,its clinical treatment is to administer hormone therapy to patients with pathological immunohistochemistry positive for progesterone receptor(PR).Objective To investigate the effect of postoperative hormonal treatment in LGESS patients at stage Ⅰ with PR positive,and analyze the influencing factors on the prognosis.Methods A retrospective comparative clinical study was conducted in 33 PR-positive and LGESS patients at stage Ⅰ who were treated in our hospital from June 1992 to October 2021.All patients were confirmed by pathology,and their pathological immunohistochemistry showed positive PR.According to whether hormone therapy(synthetic progesterone or estrogen progesterone combination therapy)was given,the patients were divided into treatment group and observation group,the impact of hormone therapy and related factors on its prognosis were analyzed.Results Of the 33 cases,13 patients were included in the hormonal treatment group and 20 patients in the observation group.With the exception of postoperative radiation(P=0.026),there were matched in age,marital and menopausal status,surgical scope,and postoperative chemotherapy.The differences were not statistically significant in PFS,OS,mean PFS(78.15 months vs 63.65 months)and mean OS(103.08 months vs 79.85 months)between the hormonal treatment group and the observation group(all P>0.05).Of the 33 cases,11 patients had a hysterectomy with ovarian conservation,and 10 cases underwent radiotherapy.The differences in PFS and OS between the ovarian preservation group and the bilateral salpingo oophorectomy group,and in PFS and OS between radiotherapy group and without radiotherapy group were not statistically significant(all P>0.05).Conclusion Hormonal treatment should be carefully selected for postoperative low-grade endometrial stromal sarcoma patients at stage Ⅰ with PR positive expression,although the mean PFS and OS in hormonal treatment group are prolonged compared with the control group,the differences between the two groups are not statistically significant.The result should be further studied with a larger sample size.关键词
Ⅰ期低级别子宫内膜间质肉瘤/术后激素治疗/孕激素受体阳性/卵巢保留/放疗Key words
stage Ⅰ low-grade endometrial stromal sarcoma/postoperative hormonal treatment/positive progesterone receptor/ovarian preservation/radiotherapy分类
医药卫生引用本文复制引用
叶艳箐,文亮,李明霞,孟元光,叶明侠..Ⅰ期PR阳性低级别子宫内膜间质肉瘤患者术后激素治疗的预后及相关因素分析[J].解放军医学院学报,2023,44(9):961-965,972,6.
