潘越 1杜磊 2翟雪 3王观筠 2徐晓丹 2孟晓琳 1刘家金 2王瑞民 2徐白萱2
作者信息
- 1. 解放军医学院,北京 100853||解放军总医院第一医学中心核医学科,北京 100853
- 2. 解放军总医院第一医学中心核医学科,北京 100853
- 3. 解放军医学院,北京 100853
- 折叠
摘要
Abstract
Background 18F-FDG PET/CT can display abnormal functional metabolism and structural changes by using image fusion technology,but there are still relatively few studies on differential diagnosis,staging and classification of thymic lymphoma.Objective To investigate the relationship between 18F-FDG PET/CT metabolic parameters of thymic lymphoma and its pathological staging and typing.Methods Patients who underwent PET/CT at the Department of Nuclear Medicine,Chinese PLA General Hospital from January 2015 to May 2022 and were diagnosed with thymic lymphoma on pathology were selected for the study.The maximum standard uptake values(SUVmax),mean standard uptake values(SUVmean),metabolic tumor volume(MTV),total lesion glycolysis(TLG)and tumor-to-normal liver standard uptake value ratio(SUVR)were recorded.Ann Arbor staging was performed based on state of lymph nodes and extra lymph nodes,and the main pathological types were classified.Spearman correlation analysis was made between metabolic parameters of 18F-FDG PET/CT and Ann Arbor stage.Results A total of 85 patients(46 males and 39 females,aged[30.34-14.48]years)were enrolled in the study,including 35 cases of primary mediastinal large B-cell lymphoma(PMBcl),29 cases of nodular sclerosis Hodgkin lymphoma(NSHL)and 19 cases of T-lymphoblastic lymphoma.There were 2,29,10 and 44 patients in Ann Arbor stages Ⅰ,Ⅱ,ⅢandⅣ,respectively.The differences of metabolic parameters between PMBCL,NSHL and T-LBL were statistically significant(P<0.05).The differences of metabolic parameters in different Ann Arbor periods were also statistically significant(P<0.05).Ann Arbor stage was positively correlated with various metabolic parameters,including TLG(rs=0.494,P<0.01),MTV(rs=0.469,P<0.01),SUVR(rs=0.378,P<0.01),SUVmax(rs=0.296,P=0.006),and SUVmean(rs=0.273,P=0.012).Conclusion There are certain differences in 18F-FDG PET/CT metabolic parameters among different pathologic types of thymic lymphomas.The metabolic parameters TLG,MTV,and SUVR are moderately correlated with the Ann Arbor stage of thymic lymphoma,which can provide evidence for clinical treatment planning.关键词
胸腺淋巴瘤/正电子发射断层成像/计算机断层成像/代谢参数/纵隔大B细胞淋巴瘤/霍奇金淋巴瘤Key words
thymic lymphoma/positron emission tomography/computed tomography/metabolic parameters/primary mediastinal large B-cell lymphoma/Hodgkin lymphoma分类
医药卫生
