解放军医学院学报2023，Vol.44Issue(9)：1060-1062,封3,4.DOI:10.12435/j.issn.2095-5227.2023.048
跨膜蛋白Lgr5作为胃肠道恶性肿瘤干细胞分子表面标记物的研究进展
Research advances in transmembrane protein Lgr5 as a molecular surface marker of stem cells from gastrointestinal malignancies
摘要
Abstract
Tumor stem cells have the property of continuous self-renewal and multi-directional differentiation,which are the main causes of tumor recurrence and drug resistance.Whether the tumor stem cells can be accurately identified and targeted for destruction has become a new direction and hot topic in the research of oncology.The transmembrane protein Lgr5 is widely expressed in the digestive tract and has extremely strong stem cell activity.In addition,it has the characteristics of high specific expression on the membrane surface of gastrointestinal malignant tumors.In-depth understanding of the molecular characteristics of Lgr5 protein will help improve the sorting efficiency of gastrointestinal tumor stem cells,which is of great significance for further research on the occurrence and development mechanism of gastrointestinal tumors,exploration of new therapeutic methods,and improvement of the overall prognosis.Based on the structural characteristics of Lgr5 protein,in combination with the signal transduction pathways and the biological activity characteristics of different gastrointestinal tumors,this paper reviews the latest progress of the Lgr5 protein as a stem cell marker in the basic research field of gastrointestinal tumors in recent years,so as to provide theoretical foundation for further research.关键词
消化道恶性肿瘤/肿瘤干细胞/Lgr5/上皮间质转化/信号通路Key words
digestive tract tumor/tumor stem cells/Lgr5/epithelial-mesenchymal transition/signaling pathway分类
医药卫生引用本文复制引用
陈志达,陈凛,郗洪庆..跨膜蛋白Lgr5作为胃肠道恶性肿瘤干细胞分子表面标记物的研究进展[J].解放军医学院学报,2023,44(9):1060-1062,封3,4.基金项目
北京市科技新星计划课题(Z181100006218011) （Z181100006218011）
军队医学科技青年培育计划拔尖项目(20QNPY113) （20QNPY113）
