精准医学杂志2024，Vol.39Issue(1)：40-43,47,5.DOI:10.13362/j.jpmed.202401010
肝素结合蛋白与降钙素原及C反应蛋白对儿童脓毒症早期诊断价值的比较
Value of heparin-binding protein versus procalcitonin and C-reactive protein in the early diagnosis of childhood sepsis
孙平平 1马少春 1蒋玉红 1李德华1
作者信息
- 1. 青岛大学附属妇女儿童医院儿内科,山东 青岛 266034
- 折叠
摘要
Abstract
Objective To investigate the clinical application value of blood heparin-binding protein(HBP),procalcitonin(PCT),and C-reactive protein(CRP)in the early diagnosis of childhood sepsis.Methods A retrospective analysis was per-formed for 20 children with general sepsis(general sepsis group),16 children with severe sepsis(severe sepsis group),and 12 chil-dren with septic shock(septic shock group)who were admitted to the pediatric intensive care unit and the neonatal intensive care unit of our hospital from November 2017 to May 2019,and 22 non-sepsis children with local infection(local infection control group)and 18 children with non-infectious disease(non-infection control group)who were admitted to the general ward during the same period of time were enrolled as control group.The levels of blood HBP,PCT,and CRP were measured and compared between groups,and the receiver operating characteristic(ROC)curve was used to investigate the value of each index in the early diagnosis of sepsis.Results The septic shock group had significantly higher levels of blood HBP and PCT than the severe sepsis group and the general sepsis group(P＜0.05),and the severe sepsis group and the general sepsis group had significantly higher levels of blood HBP and PCT than the local infection control group and the non-infection control group(P＜0.05).There was no significant diffe-rence in blood CRP between the septic shock group,the severe sepsis group,and the general sepsis group(P＞0.05),but all these three groups had a significantly higher level of blood CRP than the non-infection control group(P＜0.05).HBP had a significantly larger area under the ROC curve than PCT and CRP in the diagnosis of childhood sepsis(0.984 vs 0.954/0.897),and HBP had the best diagnostic performance at the cut-off value of 28.225μg/L,with a sensitivity of 94.4%and a specificity of 96.9%.Conclu-sion HBP has a higher application value than PCT and CRP in the early diagnosis of childhood sepsis and has a similar value to PCT in terms of clinical classification,and therefore,it can be used to guide clinical practice.关键词
脓毒症/肝素结合蛋白/降钙素原/C反应蛋白质/早期诊断/儿童Key words
Sepsis/Heparin binding protein/Procalcitonin/C-reactive protein/Early diagnosis/Child分类
医药卫生引用本文复制引用
孙平平,马少春,蒋玉红,李德华..肝素结合蛋白与降钙素原及C反应蛋白对儿童脓毒症早期诊断价值的比较[J].精准医学杂志,2024,39(1):40-43,47,5.
