农药学学报2023，Vol.25Issue(6)：1198-1205,8.DOI:10.16801/j.issn.1008-7303.2023.0068
植物病原菌对解偶联剂的抗性机制研究进展
Research progress on the resistance mechanism of plant pathogens to uncouplers
摘要
Abstract
Uncouplers represented by fluazinam show low toxicity,broad-spectrum,and high-efficiency activity,and exhibit strong virulence against pathogenic fungi,oomycetes,and bacteria.However,pathogens have developed increasingly severe resistance to fungicides due to their frequent and extensive use.Investigating the resistance mechanism of plant pathogens to fungicides will contribute to effective delaying or managing resistance.The analysis method for the resistance mechanism of fungicides is usually based on the target protein,but this does not apply to uncouplers as their antifungal efficacy may not occur through target protein binding in pathogens.It is unable to seek the changed amino acid sites in the resistant mutants,making it extremely difficult for exploring resistance mechanisms to uncouplers.This review focuses on the fluazinam and self-developed fungicide SYP-14288 in China and summarizes the research progress of their mode of action and resistance mechanism.The study could provide reference both for the scientific use of uncouplers in the field and for the disclosure of multidrug resistance mechanism,therefore enriching the research system of fungicide resistance and providing a basis for resistance management in practice.关键词
病原菌/解偶联剂/抗性机制/代谢抗性/外排抗性/抗性治理Key words
pathogens/uncoupler/resistance mechanism/metabolic resistance/efflux-mediated resistance/resistance management分类
农业科技引用本文复制引用
程星凯,张俊婷,刘鹏飞,刘西莉..植物病原菌对解偶联剂的抗性机制研究进展[J].农药学学报,2023,25(6):1198-1205,8.基金项目
国家重点研发计划项目(2022YFD1400900). Supported by National Key Research and Development Program of China(No.2022YFD1400900). （2022YFD1400900）
