农药学学报2023，Vol.25Issue(6)：1238-1249,12.DOI:10.16801/j.issn.1008-7303.2023.0074
联苯八元氧桥环新烟碱增效剂的设计、合成及其增效活性
Design,synthesis,and synergistic activity of biphenyl eight-membered oxabridge neonicotinoid analogues
摘要
Abstract
Neonicotinoids have been widely used as an important class of insecticides for controlling sap-feeding insects.However,increasing application scope and duration have led to the development of neonicotinoid resistance,decreasing their efficacy.In this study,a series of biphenyl eight-membered oxabridge neonicotinoid analogues were developed based on our previous work.The synergistic activities of target compounds in combination with imidacloprid against the cowpea aphid(Aphis Craccivora)were evaluated,and the results showed that they could effectively enhance the insecticide activities of imidacloprid against A.Craccivora.Notably,compound D3 exhibited obvious synergistic action,causing a 4.04-fold increase in the insecticide activity of imidacloprid against A.Craccivora at a combination concentration of 1 mg/L.This work holds great significance for addressing the resistance issues faced by traditional neonicotinoids.关键词
新烟碱杀虫剂/联苯八元氧桥环新烟碱类似物/吡虫啉/增效剂/增效作用Key words
neonicotinoids/biphenyl eight-membered oxabridge neonicotinoid analogues/imidacloprid/synergist/synergistic分类
化学化工引用本文复制引用
王轶平,须志平,徐晓勇,李忠..联苯八元氧桥环新烟碱增效剂的设计、合成及其增效活性[J].农药学学报,2023,25(6):1238-1249,12.基金项目
国家重点研发计划(2017YFD0200500). Supported by National Key Research and Development Program of China(No.2017YFD0200500). （2017YFD0200500）
