青岛大学学报（医学版）2023，Vol.59Issue(5)：714-719,6.DOI:10.11712/jms.2096-5532.2023.59.142
局部晚期NSCLC同步放化疗效果及预后相关因素
PREDICTIVE FACTORS FOR TREATMENT EFFICACY OF CONCURRENT CHEMORADIOTHERAPY IN PATIENTS WITH LO-CALLY ADVANCED NON-SMALL CELL LUNG CANCER AND THEIR PROGNOSIS
摘要
Abstract
Objective To investigate the value of clinical factors and metabolic parameters of 18 F-FDG PET-CT in pre-dicting the efficacy of concurrent chemoradiotherapy in patients with locally advanced non-small cell lung cancer(NSCLC)and their prognosis.Methods A retrospective analysis was performed on the clinical characteristics,tumor markers,pathological types,maximum standardized uptake values(SUVmax),and mean standardized uptake values(SUVmean)of primary tumors of 142 lo-cally advanced NSCLC patients who underwent a PET-CT scan.The cut-off values were calculated by plotting receiver operating characteristic(ROC)curves and the continuous variables were classified into two categories.Univariate and multivariate Logistic regression was used to analyze the influencing factors for objective response rate(ORR).The Kaplan-Meier method,log-rank test,and Cox regression model were used for survival analysis.Results The areas under the ROC curve(AUCs)of primary tumor SUVmax and SUVmean for predicting ORR were 0.740 and 0.665(△AUC=0.075,P=0.016),respectively.Univariate and mul-tivariate Logistic regression results showed that tumor pathological type(OR=3.827,95％CI=1.308-11.199,P=0.014),carci-noembryonic antigen(CEA)(OR=8.479,95％CI=3.015-23.848,P＜0.001),neuron-specific enolase(NSE)(OR=3.875,95％CI=1.154-9.664,P=0.004),and SUVmax(OR=4.198,95％CI=1.627-10.831,P=0.003)had predictive value for efficacy.The Kaplan-Meier survival analysis and Cox regression model showed that primary tumor SUVmax(P=0.033)was an indepen-dent predictor of overall survival(OS).Conclusion Pathological type,CEA level,NSE level,and primary tumor SUVmax can predict the efficacy of concurrent chemoradiotherapy in locally advanced NSCLC patients,and SUVmax is an independent prognos-tic factor for OS.关键词
癌,非小细胞肺/氟脱氧葡萄糖F18/正电子发射断层显像计算机体层摄影术/治疗应用/预后Key words
carcinoma,non-small-cell lung/fluorodeoxyglucose F18/positron emission tomography computed tomo-graphy/therapeutic uses/prognosis分类
医药卫生引用本文复制引用
张朋菲,周洪建,宋轶鹏..局部晚期NSCLC同步放化疗效果及预后相关因素[J].青岛大学学报（医学版）,2023,59(5):714-719,6.基金项目
烟台市重点研发计划项目(2018SFGY110) （2018SFGY110）
