青岛大学学报（医学版）2023，Vol.59Issue(5)：725-729,5.DOI:10.11712/jms.2096-5532.2023.59.157
血清学比值指标评估溃疡性结肠炎内镜下严重程度的临床价值
CLINICAL VALUE OF SEROLOGICAL RATIOS IN EVALUATING THE ENDOSCOPIC SEVERITY OF ULCERATIVE COLITIS
摘要
Abstract
Objective To investigate the clinical value of fibrinogen(FIB)/albumin(ALB)ratio,FIB/total bilirubin(TBIL)ratio,FIB/indirect bilirubin(IBIL)ratio,C-reactive protein(CRP)/ALB ratio,CRP/TBIL ratio,and CRP/IBIL ratio in assessing the endoscopic severity of ulcerative colitis(UC).Methods A retrospective analysis was performed for the clinical,la-boratory,and endoscopic data of 123 patients with UC.According to the endoscopic Mayo score,the patients were divided into en-doscopic remissiongroup with 32 patients,moderate activity group with 51 patients,and severe activity group with 40 patients.The three groups were compared in terms of each serological index and theircorrelation with endoscopic disease activity,and the receiver operating characteristic(ROC)curve was plotted to investigate the diagnostic efficiency of each index in predicting moderate-to-se-vere UC.Results There were significant differences in age and location of lesionbetween the endoscopic remission group,the moderateactivity group,and the severe activity group(H=12.36,X2=56.81,P＜0.01).There were significant differences in each serological index between the three groups(H=20.70-40.78,P＜0.001);the severe activity group had significantly higher levels of FIB/ALB,FIB/TBIL,FIB/IBIL,CRP/ALB,CRP/TBIL,CRP/IBIL,and FIB than themoderate activity groupand theendo-scopic remission group,and the moderate activity group also had significantly higher levels of these indices than theendoscopicre-mission group(Z=20.62-53.97,P＜0.05);moreover,the above indiceswere positively correlated with the endoscopic activity of UC(r=0.494-0.577,P＜0.001).The severe activity group and the moderate activity group had significantly lower serum levels of TBIL and IBIL than the endoscopicremission group(Z=21.17-41.28,P＜0.05),and these two indices were negatively correlated with the endoscopic activity of UC(r=-0.437 to-0.417,P＜0.001).The ROC curve analysis showed that CRP/TBIL and CRP/IBIL ratios were the optimal indices for the assessment of moderate-to-severe lesions in UC under endoscopy,with an area under the ROC curve of 0.824 and 0.816,respectively.Conclusion Serologicalratioindices have good performance in assessing moderate-to-severe lesions under endoscopy in UC,and CRP/TBIL and CRP/IBIL ratios aretheoptimal indices.关键词
结肠炎,溃疡性/结肠镜检查/临床实验室技术/疾病严重程度指数Key words
colitis,ulcerative/colonoscopy/clinical laboratory techniques/severity of illness index分类
医药卫生引用本文复制引用
闫静,武军,张晓静,刘爱玲,徐楠,徐永红..血清学比值指标评估溃疡性结肠炎内镜下严重程度的临床价值[J].青岛大学学报（医学版）,2023,59(5):725-729,5.基金项目
山东省自然科学基金青年科学基金项目(Z-R2020QH031) （Z-R2020QH031）
