青岛大学学报（医学版）2023，Vol.59Issue(5)：735-739,5.DOI:10.11712/jms.2096-5532.2023.59.145
2019-2021年住院儿童多重耐药菌分布及耐药性分析
AN ANALYSIS OF DISTRIBUTION AND DRUG RESISTANCE OF MULTIDRUG-RESISTANT ORGANISMS IN HOSPITALIZED CHILDREN FROM 2019 TO 2021
摘要
Abstract
Objective To analyze the distribution characteristics and drug resistance of multidrug-resistant organisms(MDRO)among hospitalized children in a hospital of Qingdao,China from 2019-2021,and to provide a reference for the preven-tion and treatment of MDRO in children in this region.Methods We analyzed the distribution and drug resistance of MDRO strains isolated from samples of hospitalized children from January 1,2019 to December 31,2021.Results From 2019 to 2021,a total of 917 MDRO strains were detected.The top four isolated strains were extended-spectrum beta-lactamase-producing Esche-richia coli(ESBL-EC,440 strains(47.98％)),methicillin-resistant Staphylococcus aureus(MRSA,234 strains(25.52％)),ESBL-producing Klebsiella pneumoniae(ESBL-KP,148 strains(16.14％)),and carbapenem-resistant Klebsiella pneumoniae(CRKP,36 strains(3.93％)).There were significant differences in the detection rates of CRKP,ESBL-KP,carbapenem-resistant Acinetobacter baumannii(CRAB),and carbapenem-resistant Pseudomonas aeruginosa(CRPA)(X2=6.276-19.335,P＜0.01).The top three MDRO-positive specimens were sputum,pus,and blood,accounting for 39.04％,28.90％,and 12.00％,respective-ly.During the three years,MDRO strains were most frequently from the department of pediatric internal medicine(368 strains,40.13％);carbapenem-resistant Escherichia coli(CREC),CRKP,and MRSA strains were most frequently from the department of pe-diatric internal medicine;ESBL-EC strains were most frequently from the department of pediatric surgery;ESBL-KP strains were mostly from the department of pediatric internal medicine and intensive care unit(ICU);CRAB and CRPA strains were mainly from the pediatric intensive care unit.CREC strains were sensitive to minocycline,tigecycline,polymyxin B,meropenem,and imi-penem,with the sensitivity rates greater than 90.00％.The sensitivity rates of CRAB to minocycline,tigecycline,and polymyxin B were 100.00％.CRPA strains were 100.00％sensitive to minocycline and polymyxin B.MRSA strains were 100.00％sensitive to vancomycin,linezolid,and tigecycline.CREC strains were＞90.00％sensitive to minocycline,tigecycline,meropenem,imipenem,ertapenem,piperacillin-tazobactam,cefoperazone-sulbactam,and amikacin.MRSA strains were the dominant Gram-positive bacte-ria detected in hospitalized children,with resistance rates of＞90.00％to erythromycin and clindamycin.Conclusion MDRO strains detected from 2019 to 2021 were mainly ESBL-EC,MRSA,and ESBL-KP.ICU and the department of pediatric internal medicine should be the key departments for the prevention and control management of MDRO infections.关键词
儿童,住院/抗药性,多种,细菌/抗药性Key words
child,hospitalized/drug resistance,multiple,bacteria/drug resistance分类
医药卫生引用本文复制引用
张丽,孙雪荣,徐莉莉,薛爱丽,张东峰..2019-2021年住院儿童多重耐药菌分布及耐药性分析[J].青岛大学学报（医学版）,2023,59(5):735-739,5.基金项目
青岛市卫生健康委员会资助项目(2021-W-JZD129) （2021-W-JZD129）
