青岛大学学报（医学版）2023，Vol.59Issue(5)：745-748,4.DOI:10.11712/jms.2096-5532.2023.59.166
ApoA1/ApoB与ST段抬高型心肌梗死病人冠脉病变程度的相关性
RELATIONSHIP BETWEEN APOA1-TO-APOB RATIO AND THE SEVERITY OF CORONARY ARTERY DISEASE IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION
摘要
Abstract
Objective To explore the value of the apolipoprotein A1-to-apolipoprotein B(ApoAl/ApoB)ratio in asses-sing the severity of coronary artery disease in patients with ST-segment elevation myocardial infarction(STEMI).Methods A retrospective analysis was performed on 566 patients with STEMI treated in our hospital.The severity of coronary artery disease was assessed by Gensini scoring based on angiogram results.The value of the ApoA1/ApoB ratio for evaluating the severity of co-ronary artery disease was analyzed by Logistic regression analysis and receiver operating characteristic(ROC)curve analysis.Re-sults The ApoA1/ApoB ratio in the high-risk group was significantly lower than that in the low-risk group(Z=-8.953,P＜0.001).The multivariable Logistic regression analysis showed that the ApoA1/ApoB ratio was an independent protective factor against coronary artery disease(OR=0.423,95％CI=0.282-0.633,P＜0.001),and the neutrophil-to-lymphocyte ratio(NLR)was an independent risk factor for coronary artery disease.The area under the ROC curve for ApoA1/ApoB assessing the severity of coronary artery disease was 0.720(95％CI=0.676-0.763,P＜0.01).Conclusion The ApoA1/ApoB ratio is an independent protective factor against coronary artery disease,which is as sensitive and specific as NLR in predicting the severity of coronary ar-tery disease.关键词
载脂蛋白A类/载脂蛋白B类/ST段抬高型心肌梗死/冠状动脉疾病/冠状血管造影术Key words
apolipoproteins A/apolipoproteins B/ST elevation myocardial infarction/coronary artery disease/coronary angiography分类
医药卫生引用本文复制引用
陈超,魏玉娇,王安阳,于宁波,田新涛,安毅..ApoA1/ApoB与ST段抬高型心肌梗死病人冠脉病变程度的相关性[J].青岛大学学报（医学版）,2023,59(5):745-748,4.基金项目
青岛市民生科技计划项目(17-3-3-29-nsh) （17-3-3-29-nsh）
