日用化学品科学2023，Vol.46Issue(12)：15-20,6.DOI:10.3969/j.issn.1006-7264.2023.12.003
光甘草定/阿魏酸/根皮素共输送纳米乳经皮渗透及美白功效研究
Transdermal penetration and whitening efficacy of the co-delivery nanoemulsions of glabridin/ferulic acid/phloretin
张目 1王曦 2罗丹 2陈丹 2张淑婷 3陈璇 3洪延涵 2刘卫4
作者信息
- 1. 广州悦荟化妆品有限公司,广东 广州 510440
- 2. 武汉百思凯瑞生物科技有限公司,湖北 武汉 430075||华中科技大学 国家纳米药物工程技术研究中心,湖北 武汉 430075
- 3. 华中科技大学 生命科学与技术学院,湖北 武汉 430074
- 4. 华中科技大学 国家纳米药物工程技术研究中心,湖北 武汉 430075||华中科技大学 生命科学与技术学院,湖北 武汉 430074
- 折叠
摘要
Abstract
The transdermal penetration and whitening efficacy of transdermal co-delivery nanoemulsions of glabridin/ferulic acid/phloretin were investigated.The transdermal penetration studies showed that,the active ingredients delivered via nanoemulsion exhibited good skin permeability and skin retention compared with the free components.The results of cellular efficacy studies showed that,the active ingredients delivered via nanoemulsion significantly inhibited tyrosinase activity and significantly reduced melanin production compared with the free components.3D melanin skin model studies showed that,compared with the negative control,the active ingredients delivered via nanoemulsion could significantly improve the apparent color tone,enhance the L* value of the melanin model and reduce the melanin content.These active ingredients delivered via nanoemulsion had good application prospect as a novel raw material with whitening efficacy.关键词
光甘草定/阿魏酸/根皮素/共输送纳米乳/经皮渗透/美白功效Key words
glabridin/ferulic acid/phloretin/co-delivery nanoemulsion/transdermal penetration/whitening efficacy分类
化学化工引用本文复制引用
张目,王曦,罗丹,陈丹,张淑婷,陈璇,洪延涵,刘卫..光甘草定/阿魏酸/根皮素共输送纳米乳经皮渗透及美白功效研究[J].日用化学品科学,2023,46(12):15-20,6.
