世界中医药2023，Vol.18Issue(19)：2796-2801,6.DOI:10.3969/j.issn.1673-7202.2023.19.015
大黄牡丹汤加味治疗慢性肾脏病高尿酸血症患者的临床疗效
Clinical efficacy of Modified Dahuang Mudan Decoction in the Treatment of Hyperuricemia in Patients with Chronic Kidney Disease
摘要
Abstract
Objective:To explore the clinical efficacy of modified Dahuang Mudan decoction in the treatment of hyperuricemia in patients with chronic kidney disease(CKD).Methods:Retrospective analysis was performed,42 cases of hyperuricemia with CKD treated with allopurinol tablets in Qinhuangdao Traditional Chinese Medicine Hospital from October 2019 to June 2022 were includ-ed as the control group;46 cases of hyperuricemia with CKD who received the treatment of modified Dahuang Mudan Decoction combined with allopurinol tablets in the same period were included as the observation group,and they were both treated for 8 weeks.The 24-hour urine protein quantification,24-hour urine uric acid level,clinical efficacy,renal function indicators such as se-rum creatinine(SCr),blood urea nitrogen(BUN),glomerular filtration rate(GFR),uric acid(UA),traditional Chinese medicine syndrome score,and incidence of adverse reactions between the two groups were compared.Results:The total effective rates of the observation group and the control group were 91.30％(42 cases/46 cases)and 66.66％(28 cases/42 cases),respectively.The re-nal function indicator SCr were(98.21±14.01)μmol/L and(121.52±29.14)μmol/L,respectively;BUN were(7.56±0.63)mmol/L and(9.24±0.98)mmol/L,respectively;serum UA were(681.43±106.73)μmol/L and(549.63±87.49)μmol/L,respectively;GFR were(28.97±9.23)mL/(min·1.732)and(24.56±8.44)mL/(min·1.732),respectively,and the differ-ence was statistically significant(P＜0.05).The uric acid metabolism indicator 24-hour urine protein quantifications were(1.01± 0.87)g and(1.94±1.12)g,respectively;24-hour uric acid levels were(398.31±32.47)μmol/L,(456.32±40.58)μmol/L,respectively,and the difference was statistically significant(P＜0.05).TNF-α levels were(45.27±5.93)μg/L and(88.62± 8.71)μg/L,respectively;IL-6 levels were(41.73±6.21)ng/L and(82.56±8.98)ng/L,respectively;CRP levels were(7.97±0.38)mg/L and(14.22±1.89)mg/L,respectively,and the difference was statistically significant(P＜0.05).The tradi-tional Chinese medicine(TCM)symptom scores of the two groups were both improved,and that of the observation group was lower than that of the control group;the differences were both statistically significant(P＜0.05).There were no adverse drug reactions in the observation group and the control group.Conclusion:The treatment of hyperuricemia in patients with CKD with modified Dahuang Mudan Decoction combined with allopurinol tablets is more effective and safe than that with allopurinol tablets alone.关键词
慢性肾脏病/高尿酸血症/别嘌醇片/大黄牡丹汤加味/肾功能/尿酸代谢/中医证候积分/炎症介质Key words
Chronic kidney disease/Hyperuricemia/Allopurinol tablets/Modified Dahuang Mudan decoction/Renal function/Uric acid metabolism/Traditional Chinese medicine syndrome score/Inflammatory mediators分类
医药卫生引用本文复制引用
张英杰,张永健,房聪聪,齐欢,朱晓亮..大黄牡丹汤加味治疗慢性肾脏病高尿酸血症患者的临床疗效[J].世界中医药,2023,18(19):2796-2801,6.基金项目
河北省中医药管理局科研计划项目(2022285) （2022285）
秦皇岛市科学技术研究与开发计划项目(202101A203) （202101A203）
