生物骨科材料与临床研究2023，Vol.20Issue(6)：66-72,7.DOI:10.3969/j.issn.1672-5972.2023.06.013
具有生物活性的多聚磷酸盐材料在骨修复中的应用:基础、进展与挑战
Bioactive polyphosphate biomaterials for bone regeneration:Fundamental,progress and challenge
摘要
Abstract
Functional orthopedic biomaterials are emerging in accordance with a better understanding of bone regeneration and progress of tissue engineering scaffolds.Inorganic polyphosphate(polyP)is a physiologically occurring biopolymer with high-energy phosphoric anhydride bonds that exists in osteoblasts and platelets,whose degradation products such as phosphate ions and energy can participate in bone regeneration and metabolism.Inspired by such events,polyphosphate biomaterials have been explored as novel bone substitutes in both amorphous and crystalline forms,along with impressive outcomes both in vitro and in vivo.This review summarizes the characteristics,physiological effects,cellular mechanisms,and material science progress of such unique biomaterial,providing basis of the application of high-energy polyphosphate in bone regeneration.In spite of its fundamentals and advances,challenges and controversies of polyphosphate are also discussed as an effort to promote its bench to bedside clinical translation in the future.关键词
多聚磷酸盐/骨再生/骨缺损修复/组织工程支架/骨科生物材料Key words
Polyphosphate(PolyP)/Bone regeneration/Bone defect repair/Tissue engineering scaffolds/Orthopedic biomaterials分类
医药卫生引用本文复制引用
刘子扬,单烁,周欢,颜廷亭,马剑雄,于腾波,马信龙,杨磊..具有生物活性的多聚磷酸盐材料在骨修复中的应用:基础、进展与挑战[J].生物骨科材料与临床研究,2023,20(6):66-72,7.基金项目
国家自然科学基金杰出青年基金(82025025) （82025025）
河北省全职引进高端人才项目(2020HBQZYC012) （2020HBQZYC012）
云南省杨磊专家工作站(202205AF150025) （202205AF150025）
河北省自然基金绿色通道项目(C2021202003) （C2021202003）
河北省自然基金创新研究群体项目(H2022202007) （H2022202007）
天津市多元投入基金项目面上项目(21JCYBJC01030) （21JCYBJC01030）
天津市多元投入基金项目重点项目(21JCZDJC01110) （21JCZDJC01110）
天津市科技局重点项目(22JCZDJC00340) （22JCZDJC00340）
