生物骨科材料与临床研究2023，Vol.20Issue(6)：73-78,83,7.DOI:10.3969/j.issn.1672-5972.2023.06.014
椎间盘退变动物模型的研究现状与进展
Experimental animal models for the biomedical research in intervertebral disc degenerative diseases
柳绪超 1易伟宏 1陈泽才 1徐震 1肖国芝 2秦雷1
作者信息
- 1. 华中科技大学协和深圳医院骨科,广东 深圳,518052
- 2. 南方科技大学医学院生物化学系,广东 深圳,518055
- 折叠
摘要
Abstract
As an age-related chronic disease and a major cause of low back pain,intervertebral disc degenerative diseases(IDDDs)have attracted increasing attention nowadays.Due to the lack of a thorough understanding of the molecular mechanisms behind the pathogenesis of IDDDs,there is no effective treatment or intervention for these diseases so far.Compared with clinical samples and cell culture models,experimental animal models which are designed to mimic human IDDDs have been established and widely used for the biomedical researches in this field.Therefore,in this article,we reviewed the commonly used IDDDs animal models which include age-induced spontaneous IDDDs model,induced IDDDs model by physical and chemical changes,genetic modification models,nutrition supply modification models,etc.The general treatment or surgical procedures,and the advantages and limitations of each model are discussed in this review.关键词
脊柱/椎间盘退化/椎间盘退行性疾病/实验动物模型/体内模型Key words
Intervertebral disc/Degeneration/Intervertebral disc degenerative diseases/Experimental animal models/In vivo models分类
基础医学引用本文复制引用
柳绪超,易伟宏,陈泽才,徐震,肖国芝,秦雷..椎间盘退变动物模型的研究现状与进展[J].生物骨科材料与临床研究,2023,20(6):73-78,83,7.
